ArticleBritish journal of cancer2013
Short-term psychological impact of the BRCA1/2 test result in women with breast cancer according to their perceived probability of genetic predisposition to cancer.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Psychological Impact ofClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Advancing Germline Genetic Testing for Breast Cancer in Resource-Restricted Settings: Evidence, Barriers, and a Practical Roadmap for Implementation.Breast cancer (Dove Medical Press) · 2026Review
- Observational
- Finding significance: New perspectives in variant classification of the RAD51 regulators, BRCA2 and beyond.DNA repair · 2023Review
- Long-Term Effects of Breast Cancer Therapy and Care: Calm after the Storm?Journal of clinical medicine · 2022Review
- Assessment of psychosocial difficulties by genetic clinicians and distress in women at high risk of breast cancer: a prospective study.European journal of human genetics : EJHG · 2022Observational
- Helping Patients Understand and Cope with BRCA Mutations.Current oncology reports · 2022Review
- How does genetic testing influence anxiety, depression, and quality of life? A hereditary breast and ovarian cancer syndrome suspects trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Online BRCA1/2 screening in the Australian Jewish community: a qualitative study.Journal of community genetics · 2020Article
- Cases in Precision Medicine: The Role of Tumor and Germline Genetic Testing in Breast Cancer Management.Annals of internal medicine · 2019Article
- Experiences and interpretations of BRCA1/2 testing among women affected by breast or ovarian cancer who received a negative result.Journal of community genetics · 2019Article
- Observational
- Emotional impact on the results of BRCA1 and BRCA2 genetic test: an observational retrospective study.Hereditary cancer in clinical practice · 2017Article
- Finding all BRCA pathogenic mutation carriers: best practice models.European journal of human genetics : EJHG · 2016Review
- The Future of Patient Engagement in the Governance of Shared Data.EGEMS (Washington, DC) · 2016Article
- Quality of Life and Psychological State in Chinese Breast Cancer Patients Who Received BRCA1/2 Genetic Testing.PloS one · 2016Article
- Primary care patient willingness for genetic testing for salt-sensitive hypertension: a cross sectional study.BMC family practice · 2013Article
- Effects of disclosing hypothetical genetic test results for salt sensitivity on salt restriction behavior.International journal of general medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of BRCA1/2 gene test result on anxiety, depression, cancer-related thought intrusion or avoidance and perceived control over cancer risk was assessed in breast cancer (BC) patients, according to their perceived probability of genetic predisposition to cancer.
methodsTwo hundred and forty-three (89% response rate) women with BC completed questionnaires after an initial genetic counselling visit (T1), of which 180 (66%) completed questionnaires again after receiving the BRCA1/2 results (T2). The discrepancy between women's perceived probability of cancer genetic predisposition at T1 and the geneticist's computed estimates was assessed.
resultsIn all, 74% of women received a negative uninformative (NU), 11% a positive BRCA1/2 and 15% an unclassified variant (UV) result. On hierarchical regression analysis, in women with a positive BRCA1/2 result (vs NU or UV), a lower perceived probability of cancer genetic predisposition than objective estimates at T1 predicted lower levels of anxiety at T2 (β=-0.28; P<0.01), whereas in women receiving a UV result (vs NU or positive BRCA1/2), a lower perceived probability of cancer genetic predisposition than objective estimates at T1 predicted higher levels of anxiety (β=0.20; P<0.01), depression (β=0.19; P<0.05) and intrusion (β=0.18; P<0.05) at T2.
conclusionThe type of BRCA1/2 test result differently affects distress according to women's perceived probability of genetic predisposition before testing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.