ArticleBritish journal of cancer2013
Biology of primary breast cancer in older women treated by surgery: with correlation with long-term clinical outcome and comparison with their younger counterparts.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human epidermal growth factor receptor 4 (HER4) is a favorable prognostic marker of breast cancer: a systematic review and meta-analysis.Oncotarget · 2016Pooled it
- Interpretable machine learning for survival prediction and risk stratification in elderly patients with breast cancer after breast-conserving surgery.Gland surgery · 2026Article
- Data-Driven SustainableACS biomaterials science & engineering · 2025Article
- Updates and Future Directions for the Nottingham Research Programme on Primary Breast Cancer in Older Women.Cancers · 2025Article
- Chemotherapy in older patients with early breast cancer.Breast (Edinburgh, Scotland) · 2024Review
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- Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival.Advances in therapy · 2023Article
- Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival.Advances in therapy · 2023Article
- Characteristics and chronologically changing patterns of late-onset breast cancer in Korean women of age ≥ 70 years: A hospital based-registry study.BMC cancer · 2022Article
- Treatment and survival outcomes in older women with primary breast cancer: A retrospective propensity score-matched analysis.Breast (Edinburgh, Scotland) · 2022Article
- Novel molecular classification of colorectal cancer and correlation with survival.Saudi journal of biological sciences · 2022Article
- A case-case analysis of women with breast cancer: predictors of interval vs screen-detected cancer.Breast cancer research and treatment · 2022Article
- The addition of radiotherapy to breast-conserving surgery improves survival for elderly patients with early breast cancer.Frontiers in oncology · 2022Article
- Age-Related Biology of Early-Stage Operable Breast Cancer and Its Impact on Clinical Outcome.Cancers · 2021Article
- Effect of radiotherapy after breast-conserving surgery in elderly patients with early breast cancer according to the AJCC 8th Edition Breast Cancer Staging System in Japan.Breast cancer (Tokyo, Japan) · 2021Article
- The Potential Use of Tumour-Based Prognostic and Predictive Tools in Older Women with Primary Breast Cancer: A Narrative Review.Oncology and therapy · 2020Review
- Nomogram for Predicting Breast Cancer-Specific Mortality of Elderly Women with Breast Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets.Breast cancer research : BCR · 2020Article
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs age advances breast cancer appears to change its biological characteristics, however, very limited data are available to define the precise differences between older and younger patients.
methodsOver 36 years (1973-2009), 1758 older (≥70 years) women with early operable primary breast cancer were managed in a dedicated clinic. In all, 813 underwent primary surgery and 575 good quality tumour samples were available for biological analysis. The pattern of biomarkers was analysed using indirect immunohistochemistry on tissue microarrays. Comparison was made with a previously characterised series of younger (<70 years) patients.
resultsThere was high expression of oestrogen receptor (ER), PgR, Bcl2, Muc1, BRCA1 and 2, E-cadherin, luminal cytokeratins, HER3, HER4, MDM2 and 4 and low expression of human epidermal growth factor receptor (HER)-2, Ki67, p53, EGFR and CK17. Oestrogen receptor and axillary stage appeared as independent prognostic factors. Unsupervised partitional clustering showed six biological clusters in older patients, five of which were common in the younger patients, whereas the low ER luminal cluster was distinct in the older series. The luminal phenotype showed better breast cancer-specific survival, whereas basal and HER2-overexpressing tumours were associated with poor outcome.
conclusionEarly operable primary breast cancer in older women appears as a distinct biological entity, with existence of a novel cluster. Overall older women showed less aggressive tumour biology and ER appeared as an independent prognostic factor alongside the time-dependent axillary stage. These biological characteristics may explain the differences in clinical outcome and should be considered in making therapeutic decisions.
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