Evidence map›Paper›PMID 23462689›Full record

ArticleEnvironmental health perspectives2013

Temporal variability of pesticide concentrations in homes and implications for attenuation bias in epidemiologic studies.

Nicole C Deziel, Mary H Ward, Erin M Bell, Todd P Whitehead, Robert B Gunier, Melissa C Friesen, John R Nuckols

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Pesticide Exposure of Residents Living in Wine Regions: Protocol and First Results of the Pestiprev Study.International journal of environmental research and public health · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Agricultural and domestic pesticides in house dust from different agricultural areas in France.Environmental science and pollution research international · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Nicole C DezielOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. dezielnc@mail.nih.gov
Mary H Ward
Erin M Bell
Todd P Whitehead
Robert B Gunier
Melissa C Friesen
John R Nuckols
National Institutes of Health · USUniversity of California, Berkeley · USColorado State University · USUniversity at Albany, State University of New York · US

Funding

Cancer Risk and Environmental ExposuresZIACP010125 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PURDUE, MARK · 2009 to 2025
$41.3M
Geographic-based exposure assessment of agricultural ch*R01CA092683 · NCI · COLORADO STATE UNIVERSITY-FORT COLLINS · PI NUCKOLS, JOHN R · 2001 to 2004
$949k
Intramural NIH HHSNCI NIH HHS R01 CA092683NCI NIH HHS R01CA092683
6 · The paper itself

Abstract

backgroundResidential pesticide exposure has been linked to adverse health outcomes in adults and children. High-quality exposure estimates are critical for confirming these associations. Past epidemiologic studies have used one measurement of pesticide concentrations in carpet dust to characterize an individual's average long-term exposure. If concentrations vary over time, this approach could substantially misclassify exposure and attenuate risk estimates.

objectivesWe assessed the repeatability of pesticide concentrations in carpet dust samples and the potential attenuation bias in epidemiologic studies relying on one sample.

methodsWe collected repeated carpet dust samples (median = 3; range, 1-7) from 21 homes in Fresno County, California, during 2003-2005. Dust was analyzed for 13 pesticides using gas chromatography-mass spectrometry. We used mixed-effects models to estimate between- and within-home variance. For each pesticide, we computed intraclass correlation coefficients (ICCs) and the estimated attenuation of regression coefficients in a hypothetical case-control study collecting a single dust sample.

resultsThe median ICC was 0.73 (range, 0.37-0.95), demonstrating higher between-home than within-home variability for most pesticides. The expected magnitude of attenuation bias associated with using a single dust sample was estimated to be ≤ 30% for 7 of the 13 compounds evaluated.

conclusionsFor several pesticides studied, use of one dust sample to represent an exposure period of approximately 2 years would not be expected to substantially attenuate odds ratios. Further study is needed to determine if our findings hold for longer exposure periods and for other pesticides.

Indexed as

BiasAir Pollution, IndoorAnimalsDustEpidemiologic StudiesHumansPesticidesRegression AnalysisDustPesticides

Identifiers

PMID23462689
PMCPMC3672902
OpenAlexW2026160112

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.