ArticleEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V2014
Microneedle/nanoencapsulation-mediated transdermal delivery: mechanistic insights.
Article in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Alopecia Areata: Pathogenesis, Diagnosis, and Therapies.MedComm · 2025Review
- Microneedle-Assisted Delivery of Curcumin: Evaluating the Effects of Needle Length and Formulation.Micromachines · 2025Article
- Consensus Recommendations for the Management of Androgenetic Alopecia in Egypt: A Modified Delphi Study.Clinical, cosmetic and investigational dermatology · 2025Article
- Vitamin D3 capsulation using maillard reaction complex of sodium caseinate and tragacanth gum.Food chemistry: X · 2024Article
- A Hollow Microneedle Equipped with a Micropillar for Improved Needle Insertion and Injection of Drug Solution.Pharmaceutical research · 2024Article
- Particle Size Effect of Curcumin Nanocrystals on Transdermal and Transfollicular Penetration by Hyaluronic Acid-Dissolving Microneedle Delivery.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Preparation and Evaluation of Liposomes and Niosomes Containing Total Ginsenosides for Anti-Photoaging Therapy.Frontiers in bioengineering and biotechnology · 2022Article
- Fused Deposition Modeling 3D Printing: Test Platforms for Evaluating Post-Fabrication Chemical Modifications and In-Vitro Biological Properties.Pharmaceutics · 2019Article
- Design, formulation and evaluation of novel dissolving microarray patches containing a long-acting rilpivirine nanosuspension.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Mini-Review: Assessing the Potential Impact of Microneedle Technologies on Home Healthcare Applications.Medicines (Basel, Switzerland) · 2018Review
- The Influence of Solid Microneedles on the Transdermal Delivery of Selected Antiepileptic Drugs.Pharmaceutics · 2016Article
- PLGA-loaded nanomedicines in melanoma treatment: Future prospect for efficient drug delivery.The Indian journal of medical research · 2016Review
- Microneedles: A New Frontier in Nanomedicine Delivery.Pharmaceutical research · 2016Review
- Solid-phase microextraction/gas chromatography-mass spectrometry method optimization for characterization of surface adsorption forces of nanoparticles.Analytical and bioanalytical chemistry · 2014Article
- Effect of formulation variables on preparation of celecoxib loaded polylactide-co-glycolide nanoparticles.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A systematic study was undertaken to gain more insight into the mechanism of transdermal delivery of nanoencapsulated model dyes across microneedle (MN)-treated skin, a complex process not yet explored. Rhodamine B (Rh B) and fluorescein isothiocyanate (FITC) as model hydrophilic and hydrophobic small/medium-size molecules, respectively, were encapsulated in poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) and delivered through full thickness porcine skin pretreated with MN array. Permeation through MN-treated skin was affected by physicochemical characteristics of NPs and the encapsulated dyes. Dye flux was enhanced by smaller particle size, hydrophilicity, and negative zeta potential of NPs. Regarding encapsulated dyes, solubility at physiological pH and potential interaction with skin proteins proved to outweigh molecular weight as determinants of skin permeation. Data were verified using confocal laser scanning microscopy imaging. Findings coupled with the literature data are supportive of a mechanism involving influx of NPs, particularly of smaller size, deep into MN-created channels, generating depot dye-rich reservoirs. Molecular diffusion of the released dye across viable skin layers proceeds at a rate determined by its molecular characteristics. Data obtained provide mechanistic information of importance to the development of formulation strategies for more effective intradermal and transdermal MN-mediated delivery of nanoencapsulated therapeutic agents.
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Registered trials
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