Evidence map›Paper›PMID 23461716›Full record

SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2014

Use of pre-operative steroids in liver resection: a systematic review and meta-analysis.

Arthur J Richardson, Jerome M Laurence, Vincent W T Lam

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Immune capacity determines outcome following surgery or trauma: a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020
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  19. Enhanced Recovery After Surgery: Hepatobiliary.The Surgical clinics of North America · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Arthur J RichardsonDepartment of Surgery, Westmead Hospital, Sydney, NSW, Australia; Discipline of Surgery, University of Sydney, Sydney, NSW, Australia.
Jerome M Laurence
Vincent W T Lam
Westmead Hospital · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBy attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications.

methodsA systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed.

resultsFive RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance.

conclusionPre-operative steroids may be associated with a clinically significant benefit in liver resection.

Indexed as

BilirubinBiomarkersChi-Square DistributionDrug Administration ScheduleHepatectomyHumansInflammation MediatorsInterleukin-6Odds RatioPreoperative CareProthrombin TimeRisk FactorsSteroidsSystemic Inflammatory Response SyndromeTreatment OutcomeBilirubinBiomarkersIL6 protein, humanInflammation MediatorsInterleukin-6Steroids

Identifiers

PMID23461716
PMCPMC3892310
OpenAlexW2108699207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.