ArticleAddiction biology2014
μ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche.
Article in Addiction biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Elevated customary alcohol consumption attenuates opioid effects.Pharmacology, biochemistry, and behavior · 2021Article
- Sex and Age Effects on Neurobehavioral Toxicity Induced by Binge Alcohol.Brain plasticity (Amsterdam, Netherlands) · 2020Review
- A novel mouse model for vulnerability to alcohol dependence induced by early-life adversity.Neurobiology of stress · 2020Article
- Article
- Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders.Behavioural brain research · 2019Article
- Activation of neural stem cells from quiescence drives reactive hippocampal neurogenesis after alcohol dependence.Neuropharmacology · 2018Article
- Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol.Journal of neuroinflammation · 2017Article
- Evaluation of TLR4 Inhibitor, T5342126, in Modulation of Ethanol-Drinking Behavior in Alcohol-Dependent Mice.Alcohol and alcoholism (Oxford, Oxfordshire) · 2016Article
- Genes and Alcohol Consumption: Studies with Mutant Mice.International review of neurobiology · 2016Review
- Effects of addictive drugs on adult neural stem/progenitor cells.Cellular and molecular life sciences : CMLS · 2016Review
- GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Alcohol and adult hippocampal neurogenesis: promiscuous drug, wanton effects.Progress in neuro-psychopharmacology & biological psychiatry · 2014Review
- Alcohol exposure inhibits adult neural stem cell proliferation.Experimental brain research · 2014Article
- Ectopic hippocampal neurogenesis in adolescent male rats following alcohol dependence.Addiction biology · 2014Article
- Article
- BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice.Frontiers in integrative neuroscience · 2013Article
- The Interplay between the Hippocampus and Amygdala in Regulating Aberrant Hippocampal Neurogenesis during Protracted Abstinence from Alcohol Dependence.Frontiers in psychiatry · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Ethanol exposure and withdrawal alter the generation of new neurons in the adult hippocampus. The endogenous opioid system, particularly the μ-opioid receptor (MOR), can modulate neural progenitors and also plays a critical role in ethanol drinking and dependence. In the present study, we sought to determine whether MOR contributes to the effects of ethanol on the dentate gyrus (DG) neurogenic niche. MOR wild-type (WT), heterozygous (Het) and knockout (KO) littermates were subjected to voluntary ethanol drinking in repeated limited-access two-bottle choice (2BC) sessions. MOR deficiency did not alter progenitor proliferation, neuronal differentiation and maturation, apoptosis or microglia in ethanol-naïve mice. When exposed to five consecutive weeks of 2BC, MOR mutant mice exhibited a gene-dosage-dependent reduction of ethanol consumption compared with WT mice. Introducing a week of ethanol deprivation between each week of 2BC increased ethanol consumption in all genotypes and produced equivalent intakes in WT, Het and KO mice. Under the latter paradigm, ethanol drinking decreased progenitor proliferation and neuronal differentiation in the DG of WT mice. Interestingly, WT mice exhibited a strong negative correlation between ethanol intake and proliferation, which was disrupted in Het and KO mice. Moreover, MOR deficiency blocked the effect of ethanol on neuronal differentiation. MOR deficiency also protected against the neuroimmune response to ethanol drinking. Finally, chronic binge drinking induced a paradoxical decrease in apoptosis, which was independent of MOR. Altogether, our data suggest that MOR is implicated in some of the neuroplastic changes produced by chronic ethanol exposure in the DG.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.