ArticlePloS one2013
Abnormal brain functional connectivity of the hypothalamus in cluster headaches.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- White matter microstructural alterations in episodic cluster headache outside attacks: a tract-based spatial statistics study.The journal of headache and pain · 2026Article
- Hallmarks of primary headache: part 3 - cluster headache.The journal of headache and pain · 2025Review
- Article
- Cluster Headache and Migraine Shared and Unique Insights: Neurophysiological Implications, Neuroimaging, and Biomarkers: A Comprehensive Review.Journal of clinical medicine · 2025Review
- MRI-based analysis of the microstructure of the thalamus and hypothalamus and functional connectivity between cortical networks in episodic cluster headache.The journal of headache and pain · 2025Article
- Potential hypothalamic mechanisms in trigeminal neuropathic pain: a comparative analysis with migraine and cluster headache.The journal of headache and pain · 2024Review
- Altered functional connectivity of the thalamus and salience network in patients with cluster headache: a pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Review
- Alterations of the structural covariance network in the hypothalamus of patients with cluster headache.Journal of neurology · 2022Article
- Regional cerebral blood flow as predictor of response to occipital nerve block in cluster headache.The journal of headache and pain · 2021Article
- Pharmacotherapy for Cluster Headache.CNS drugs · 2020Review
- Electrophysiology and Structural Connectivity of the Posterior Hypothalamic Region: Much to Learn From a Rare Indication of Deep Brain Stimulation.Frontiers in human neuroscience · 2020Article
- Understanding Cluster Headache Using Magnetic Resonance Imaging.Frontiers in neurology · 2020Review
- Cluster headache: insights from resting-state functional magnetic resonance imaging.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Review
- Brain functional connectivity in headache disorders: A narrative review of MRI investigations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Review
- Update on the pathophysiology of cluster headache: imaging and neuropeptide studies.Journal of pain research · 2019Review
- Migraine and cluster headache - the common link.The journal of headache and pain · 2018Review
- Functional Neuroimaging in Trigeminal Autonomic Cephalalgias.Annals of Indian Academy of Neurology · 2018Review
- Sex-based differences in brain alterations across chronic pain conditions.Journal of neuroscience research · 2017Review
- Recent neuroimaging advances in the study of primary headaches.Current pain and headache reports · 2015Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to detect the abnormality of the brain functional connectivity of the hypothalamus during acute spontaneous cluster headache (CH) attacks ('in attack') and headache-free intervals ('out of attack') using resting-state functional magnetic resonance imaging (RS-fMRI) technique. The RS-fMRI data from twelve male CH patients during 'in attack' and 'out of attack' periods and twelve age- and sex-matched normal controls were analyzed by the region-of-interest -based functional connectivity method using SPM5 software. Abnormal brain functional connectivity of the hypothalamus is present in CH, which is located mainly in the pain system during the spontaneous CH attacks. It extends beyond the pain system during CH attack intervals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.