ArticlePloS one2013
Risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Prenatal and childhood infections and risk of epilepsy.European journal of epidemiology · 2025Article
- Epilepsy in Cerebral Palsy: Unraveling Prevalence, Risk Factors, and Subtype Associations in a Large-Scale Population Study.Medicina (Kaunas, Lithuania) · 2024Article
- Beyond TORCH: A narrative review of the impact of antenatal and perinatal infections on the risk of disability.Neuroscience and biobehavioral reviews · 2023Review
- Targeting the metabolic profile of amino acids to identify the key metabolic characteristics in cerebral palsy.Frontiers in molecular neuroscience · 2023Article
- Characterisation of the consequences of maternal immune activation on distinct cell populations in the developing rat spinal cord.Journal of anatomy · 2022Article
- Childhood seizures after prenatal exposure to maternal influenza infection: a population-based cohort study from Norway, Australia and Canada.Archives of disease in childhood · 2022Article
- Antecedents of epilepsy and seizures among children born at extremely low gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2019Observational
- Alterations in regional shape on ipsilateral and contralateral cortex contrast in children with unilateral cerebral palsy and are predictive of multiple outcomes.Human brain mapping · 2016Article
- Maternal Infections During Pregnancy and Cerebral Palsy in the Child.Pediatric neurology · 2016Article
- Systematic Review of Cerebral Palsy Registries/Surveillance Groups: Relationships between Registry Characteristics and Knowledge Dissemination.International journal of physical medicine & rehabilitation · 2015Article
- Perinatal neuroprotection.F1000prime reports · 2014Review
- The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy.Epilepsy research and treatment · 2014Article
- Maternal infections during pregnancy and cerebral palsy: a population-based cohort study.Paediatric and perinatal epidemiology · 2013Article
- Congenital cerebral palsy and prenatal exposure to self-reported maternal infections, fever, or smoking.American journal of obstetrics and gynecology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimMaternal infections during pregnancy have been associated with several neurological disorders in the offspring. However, given the lack of specificity for both the exposures and the outcomes, other factors related to infection such as impaired maternal immune function may be involved in the causal pathway. If impaired maternal immune function plays a role, we would expect infection before pregnancy to be associated with these neurological outcomes. METHODS/PRINCIPAL
findingsThe study population included all first-born singletons in Denmark between January 1 1982 and December 31 2004. We identified women who had hospital-recorded infections within the 5 year period before pregnancy, and women who had hospital-recorded infections during pregnancy. We grouped infections into either infections of the genitourinary system, or any other infections. Cox models were used to estimate adjusted hazard ratios (aHRs) with 95% confidence interval (CI). Maternal infection of the genitourinary system during pregnancy was associated with an increased risk of cerebral palsy (aHR = 1.63, 95% CI: 1.34-1.98) and epilepsy (aHR = 1.27, 95% CI: 1.13-1.42) in the children, compared to children of women without infections during pregnancy. Among women without hospital-recorded infections during pregnancy, maternal infection before pregnancy was associated with an increased risk of epilepsy (aHR = 1.35, 95% CI: 1.21-1.50 for infections of the genitourinary system, and HR = 1.12, 95% CI: 1.03-1.22 for any other infections) and a slightly higher risk of cerebral palsy (aHR = 1.20, 95% CI: 0.96-1.49 for infections of the genitourinary system, and HR = 1.23, 95% CI: 1.06-1.43 for any other infections) in the children, compared to children of women without infections before (and during) pregnancy.
conclusionsThese findings indicate that the maternal immune system, maternal infections, or factors related to maternal immune function play a role in the observed associations between maternal infections before pregnancy and cerebral diseases in the offspring.
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