ArticlePloS one2013
Preferential invasion by Plasmodium merozoites and the self-regulation of parasite burden.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Ficolin-1 in pediatricInfection and immunity · 2025Article
- Review
- YOLO-PAM: Parasite-Attention-Based Model for Efficient Malaria Detection.Journal of imaging · 2023Article
- Evaluation of an Innovative Point-of-Care Rapid Diagnostic Test for the Identification of Imported Malaria Parasites in China.Tropical medicine and infectious disease · 2023Article
- Article
- Erythrocyte tropism of malarial parasites: The reticulocyte appeal.Frontiers in microbiology · 2022Review
- Zoonotic Malaria: Non-Pathogens (Basel, Switzerland) · 2021Review
- Of membranes and malaria: phospholipid asymmetry in Plasmodium falciparum-infected red blood cells.Cellular and molecular life sciences : CMLS · 2021Review
- Breakdown in membrane asymmetry regulation leads to monocyte recognition of P. falciparum-infected red blood cells.PLoS pathogens · 2021Article
- Diagnostic Methods for Non-Falciparum Malaria.Frontiers in cellular and infection microbiology · 2021Review
- Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains.PLoS computational biology · 2020Article
- An epigrammatic status of the 'RSC medicinal chemistry · 2020Review
- Effectiveness of a Malaria Surveillance Strategy Based on Active Case Detection during High Transmission Season in the Peruvian Amazon.International journal of environmental research and public health · 2018Article
- Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion.Malaria journal · 2018Article
- Examining the Reticulocyte Preference of TwoFrontiers in microbiology · 2018Article
- Malaria-Related Hospitalizations in the United States, 2000-2014.The American journal of tropical medicine and hygiene · 2017Article
- The dangers of accepting a single diagnosis: case report of concurrent Plasmodium knowlesi malaria and dengue infection.Malaria journal · 2017Article
- Can Mixed Parasite Infections Thwart Targeted Malaria Elimination Program in India?BioMed research international · 2017Article
- Comparison of mathematical frameworks for modeling erythropoiesis in the context of malaria infection.Mathematical biosciences · 2015Article
- From within host dynamics to the epidemiology of infectious disease: Scientific overview and challenges.Mathematical biosciences · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The preferential invasion of particular red blood cell (RBC) age classes may offer a mechanism by which certain species of Plasmodia regulate their population growth. Asexual reproduction of the parasite within RBCs exponentially increases the number of circulating parasites; limiting this explosion in parasite density may be key to providing sufficient time for the parasite to reproduce, and for the host to develop a specific immune response. It is critical that the role of preferential invasion in infection is properly understood to model the within-host dynamics of different Plasmodia species. We develop a simulation model to show that limiting the range of RBC age classes available for invasion is a credible mechanism for restricting parasite density, one which is equally as important as the maximum parasite replication rate and the duration of the erythrocytic cycle. Different species of Plasmodia that regularly infect humans exhibit different preferences for RBC invasion, with all species except P. falciparum appearing to exhibit a combination of characteristics which are able to self-regulate parasite density.
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