ArticlePloS one2013
Protective effect of borage seed oil and gamma linolenic acid on DNA: in vivo and in vitro studies.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- Fatty Acid Profile and Some Useful Biological Aspects of Borage, Calophyllum, and Prickly Pear Seed Oils: Implications for Health and Dietary Use.Antioxidants (Basel, Switzerland) · 2025Article
- Nutraceutical Potential and Food Safety of Fructose in Soda and Diet Beverages.Foods (Basel, Switzerland) · 2025Article
- In Vivo and In Vitro Studies Assessing the Safety of Monosodium Glutamate.Foods (Basel, Switzerland) · 2024Article
- Exploring the Nutritional Potential and Functionality of Hemp and Rapeseed Proteins: A Review on Unveiling Anti-Nutritional Factors, Bioactive Compounds, and Functional Attributes.Plants (Basel, Switzerland) · 2024Review
- Review
- Role of Glucosinolates in the Nutraceutical Potential of Selected Cultivars ofFoods (Basel, Switzerland) · 2021Article
- Health-Promoting Properties of Borage Seed Oil Fractionated by Supercritical Carbon Dioxide Extraction.Foods (Basel, Switzerland) · 2021Article
- Ahiflower Oil-The Rising GLA Alternative to Evening Primrose for Women & Vegans.Integrative medicine (Encinitas, Calif.) · 2021Article
- Antioxidant Activity of Hemp (Antioxidants (Basel, Switzerland) · 2021Article
- Herbal Additives Substantially Modify Antioxidant Properties and Tocopherol Content of Cold-Pressed Oils.Antioxidants (Basel, Switzerland) · 2021Article
- In Vivo and In Vitro Assays Evaluating the Biological Activity of Taurine, Glucose and Energetic Beverages.Molecules (Basel, Switzerland) · 2021Article
- Incorporation of docetaxel and thymoquinone in borage nanoemulsion potentiates their antineoplastic activity in breast cancer cells.Scientific reports · 2020Article
- Food Safety and Nutraceutical Potential of Caramel Colour Class IV Using In Vivo and In Vitro Assays.Foods (Basel, Switzerland) · 2019Article
- Toxicological Studies of Czech Beers and Their Constituents.Foods (Basel, Switzerland) · 2019Article
- Biological Effects of Food Coloring in In Vivo and In Vitro Model Systems.Foods (Basel, Switzerland) · 2019Article
- Effects of the electrical conductivity of a soilless culture system on gamma linolenic acid levels in borage seed oil.PloS one · 2019Article
- Article
- Managing Rheumatoid Arthritis with Dietary Interventions.Frontiers in nutrition · 2017Review
- EFFICIENCY OF BORAGE SEEDS OIL AGAINST GAMMA IRRADIATION-INDUCED HEPATOTOXICITY IN MALE RATS: POSSIBLE ANTIOXIDANT ACTIVITY.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Article
- Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants.Nutrients · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Borage (Borago officinalis L.) seed oil has been used as a treatment for various degenerative diseases. Many useful properties of this oil are attributed to its high gamma linolenic acid content (GLA, 18:3 ω-6). The purpose of this study was to demonstrate the safety and suitability of the use of borage seed oil, along with one of its active components, GLA, with respect to DNA integrity, and to establish possible in vivo toxic and in vitro cytotoxic effects. In order to measure these properties, five types of assays were carried out: toxicity, genotoxicity, antigenotoxicity, cytotoxicity (using the promyelocytic leukaemia HL60 cell line), and life span (in vivo analysis using the Drosophila model). Results showed that i) Borage seed oil is not toxic to D. melanogaster at physiological concentrations below 125 µl/ml and the studies on GLA indicated non-toxicity at the lowest concentration analyzed ii) Borage seed oil and GLA are DNA safe (non-genotoxic) and antimutagenic compared to hydrogen peroxide, thereby confirming its antioxidant capacity; iii) Borage seed oil and GLA exhibited cytotoxic activity in low doses (IC50 of 1 µl/ml and 0.087 mM, respectively) iv) Low doses of borage seed oil (0.19%) increased the health span of D. melanogaster; and v) GLA significantly decreased the life span of D. melanogaster.Based on the antimutagenic and cytotoxic effects along with the ability to increase the health span, we propose supplementation with borage seed oil rather than GLA, because it protects DNA by modulating oxidative genetic damage in D. melanogaster, increases the health span and exerts cytotoxic activity towards promyelocytic HL60 cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.