ArticlePloS one2013
Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 73 citations in OpenAlex.
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- Targeting IL-6 receptor mediated metabolic pathways to control Th17 cell differentiation and inflammatory responses.Frontiers in immunology · 2025Article
- FXR-regulated COX6A2 triggers mitochondrial apoptosis of pancreatic β-cell in type 2 diabetes.Cell death & disease · 2024Article
- Transcriptome Analysis Reveals Immune and Antioxidant Defense Mechanisms in theAnimals : an open access journal from MDPI · 2024Article
- Cytosolic nucleic acid sensing and mitochondrial transcriptomic changes as early triggers of metabolic disease in db/db mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Identification of differentially expressed genes, pathways, and immune infiltration in diabetes.Clinics (Sao Paulo, Brazil) · 2024Article
- COX6A2 deficiency leads to cardiac remodeling in human pluripotent stem cell-derived cardiomyocytes.Stem cell research & therapy · 2023Article
- Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC.PLoS genetics · 2023Article
- Proteomic changes in various organs of Haemaphysalis longicornis under long-term starvation.PLoS neglected tropical diseases · 2022Article
- Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia.Molecular psychiatry · 2022Article
- A genome-wide association study in human lymphoblastoid cells supports safety of mitochondrial complex I inhibitor.Mitochondrion · 2021Article
- PDX1Nature communications · 2021Article
- Effects of imatinib on vascular insulin sensitivity and free fatty acid transport in early weight gain.PloS one · 2021Article
- Complex IV subunit isoform COX6A2 protects fast-spiking interneurons from oxidative stress and supports their function.The EMBO journal · 2020Article
- Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke.Experimental neurology · 2020Article
- Diet induced the change of mtDNA copy number and metabolism in Angus cattle.Journal of animal science and biotechnology · 2020Article
- Non-monotonic dose-response effects of arsenic on glucose metabolism.Toxicology and applied pharmacology · 2019Article
- Genomic approaches to identify hybrids and estimate admixture times in European wildcat populations.Scientific reports · 2019Article
- Ergot alkaloid exposure during gestation alters: 3. Fetal growth, muscle fiber development, and miRNA transcriptome1.Journal of animal science · 2019Article
- A survey of transcriptome complexity in Sus scrofa using single-molecule long-read sequencing.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 4 countries.
Funding
Abstract
Oxidative phosphorylation in mitochondria is responsible for 90% of ATP synthesis in most cells. This essential housekeeping function is mediated by nuclear and mitochondrial genes encoding subunits of complex I to V of the respiratory chain. Although complex IV is the best studied of these complexes, the exact function of the striated muscle-specific subunit COX6A2 is still poorly understood. In this study, we show that Cox6a2-deficient mice are protected against high-fat diet-induced obesity, insulin resistance and glucose intolerance. This phenotype results from elevated energy expenditure and a skeletal muscle fiber type switch towards more oxidative fibers. At the molecular level we observe increased formation of reactive oxygen species, constitutive activation of AMP-activated protein kinase, and enhanced expression of uncoupling proteins. Our data indicate that COX6A2 is a regulator of respiratory uncoupling in muscle and we demonstrate that a novel and direct link exists between muscle respiratory chain activity and diet-induced obesity/insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.