ArticlePloS one2013
Genome-wide copy number variation analysis in extended families and unrelated individuals characterized for musical aptitude and creativity in music.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sensogenomics of music and Alzheimer's disease: An interdisciplinary view from neuroscience, transcriptomics, and epigenomics.Frontiers in aging neuroscience · 2023Pooled it
- The influence of serotonergic multilocus genetic variants and parent-child relationship on adolescent creativity.Scientific reports · 2025Article
- Rhythmic Roots: The Adaptive Functions of Vocal Isochrony and Its Role in Human Music and Language Evolution.Psihologijske teme = Psychological themes = Psychological topics · 2025Article
- Decoding the peripheral transcriptomic and meta-genomic response to music in autism spectrum disorder via saliva-based RNA sequencing.Frontiers in molecular biosciences · 2025Article
- Using rare genetic mutations to revisit structural brain asymmetry.Nature communications · 2024Article
- Review
- Genome-wide study of copy number variation implicates multiple novel loci for schizophrenia risk in Han Chinese family trios.iScience · 2021Article
- Human Genomics and the Biocultural Origin of Music.International journal of molecular sciences · 2021Review
- How far musicality and perfect pitch are derived from genetic factors?Journal of applied genetics · 2020Review
- Clustered Protocadherins Emerge as Novel Susceptibility Loci for Mental Disorders.Frontiers in neuroscience · 2020Review
- Long-Term Musical Training Alters Auditory Cortical Activity to the Frequency Change.Frontiers in human neuroscience · 2020Article
- Article
- Fractionating auditory priors: A neural dissociation between active and passive experience of musical sounds.PloS one · 2019Article
- Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice.Scientific reports · 2018Article
- A Novel Relationship for Schizophrenia, Bipolar, and Major Depressive Disorder. Part 8: a Hint from Chromosome 8 High Density Association Screen.Molecular neurobiology · 2017Article
- The Paradox of Isochrony in the Evolution of Human Rhythm.Frontiers in psychology · 2017Article
- Convergent evidence for the molecular basis of musical traits.Scientific reports · 2016Review
- Article
- Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9.Journal of molecular cell biology · 2015Article
- Defining the biological bases of individual differences in musicality.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
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9 authors.
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Abstract
Music perception and practice represent complex cognitive functions of the human brain. Recently, evidence for the molecular genetic background of music related phenotypes has been obtained. In order to further elucidate the molecular background of musical phenotypes we analyzed genome wide copy number variations (CNVs) in five extended pedigrees and in 172 unrelated subjects characterized for musical aptitude and creative functions in music. Musical aptitude was defined by combination of the scores of three music tests (COMB scores): auditory structuring ability, Seashores test for pitch and for time. Data on creativity in music (herein composing, improvising and/or arranging music) was surveyed using a web-based questionnaire.Several CNVRs containing genes that affect neurodevelopment, learning and memory were detected. A deletion at 5q31.1 covering the protocadherin-α gene cluster (Pcdha 1-9) was found co-segregating with low music test scores (COMB) in both sample sets. Pcdha is involved in neural migration, differentiation and synaptogenesis. Creativity in music was found to co-segregate with a duplication covering glucose mutarotase gene (GALM) at 2p22. GALM has influence on serotonin release and membrane trafficking of the human serotonin transporter. Interestingly, genes related to serotonergic systems have been shown to associate not only with psychiatric disorders but also with creativity and music perception. Both, Pcdha and GALM, are related to the serotonergic systems influencing cognitive and motor functions, important for music perception and practice. Finally, a 1.3 Mb duplication was identified in a subject with low COMB scores in the region previously linked with absolute pitch (AP) at 8q24. No differences in the CNV burden was detected among the high/low music test scores or creative/non-creative groups. In summary, CNVs and genes found in this study are related to cognitive functions. Our result suggests new candidate genes for music perception related traits and supports the previous results from AP study.
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