ArticlePediatrics2013
Triglyceride to HDL-C ratio and increased arterial stiffness in children, adolescents, and young adults.
Article in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 86 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it, 176 citations in OpenAlex.
- Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2015Guideline
- Exercise effects on arterial stiffness and heart health in children with excess weight: The SMART RCT.International journal of obesity (2005) · 2020Trial
- Improvement in liver histology is associated with reduction in dyslipidemia in children with nonalcoholic fatty liver disease.Journal of pediatric gastroenterology and nutrition · 2015Trial
- Arterial Stiffness and Central Hemodynamics in South Asian, African American, and White Adolescents and Young Adults-The Charisma Study.American journal of hypertension · 2026Article
- Association between TG/HDL-C ratio or triglyceride-glucose index and mean arterial pressure in patients with myocardial infarction.Scientific reports · 2025Article
- Adolescent hyperandrogenism: diagnostic challenges and therapeutic approaches.World journal of pediatrics : WJP · 2025Review
- Identifying Cardiovascular Disease Risk Endotypes of Adolescent Major Depressive Disorder Using Exploratory Unsupervised Machine Learning.JAACAP open · 2025Article
- The relationship between triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular high risk: a cross-sectional investigation.Frontiers in endocrinology · 2025Article
- Body composition shapes cardiometabolic risk in children with multifactorial dyslipidemia.Frontiers in nutrition · 2025Article
- A Cross-Sectional Study of the Association Between Uric Acid-to-High-Density Lipoprotein Cholesterol Ratio and Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Do Children's Health Behaviors Buffer the Impact of Cumulative Environmental Stress on Emerging Cardiometabolic Risk?Journal of the American Heart Association · 2024Article
- Cumulative environmental stress and emerging cardiometabolic risk during childhood.Pediatric obesity · 2024Article
- The association of plasma asprosin with anthropometric and metabolic parameters in Korean children and adolescents.Frontiers in endocrinology · 2024Article
- An augmented Mendelian randomization approach provides causality of brain imaging features on complex traits in a single biobank-scale dataset.PLoS genetics · 2023Article
- Cross-sectional associations between phthalates, phenols, and parabens with metabolic syndrome risk during early-to-mid adolescence among a cohort of Mexican youth.Environmental research · 2023Article
- Body composition in pediatric celiac disease and metabolic syndrome component risk-an observational study.Pediatric research · 2023Observational
- Effects of a 12-week walking intervention on circulating lipid profiles and adipokines in normal weight and abdominal obese female college students.Journal of exercise science and fitness · 2023Article
- Novel Metabolic Subtypes in Pregnant Women and Risk of Early Childhood Obesity in Offspring.JAMA network open · 2023Article
- Is There a Role for Imaging Youth at Risk of Atherosclerosis?Current atherosclerosis reports · 2023Review
- The influence of somatic maturity on the relationship between the triglyceride/high-density lipoprotein ratio and vascular health in children and adolescents with dyslipidemia.American journal of human biology : the official journal of the Human Biology Council · 2023Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveLipid levels are linked to early atherosclerosis. Risk stratification may be improved by using triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), which relates to arterial stiffness in adults. We tested whether TG/HDL-C was an independent predictor of arterial stiffness in youth.
methodsSubjects 10 to 26 years old (mean 18.9 years, 39% male, 56% non-Caucasian, n = 893) had laboratory, anthropometric, blood pressure, and arterial stiffness data collected (brachial distensibility, augmentation index, carotid-femoral pulse-wave velocity). Subjects were stratified into tertiles of TG/HDL-C (low, n = 227; mid, n = 288; high, n = 379).
resultsThere was a progressive rise in cardiovascular (CV) risk factors and arterial stiffness across TG/HDL-C ratio. The high TG/HDL-C ratio group had the stiffest vessels (all P < .03 by analysis of variance). TG/HDL-C as a continuous variable was an independent determinant of brachial distensibility in CV risk factor adjusted model and for carotid-femoral pulse-wave velocity in obese subjects, with trend for higher augmentation index.
conclusionsTG/HDL-C, an estimate of small, dense low-density lipoprotein cholesterol, is an independent determinant of arterial stiffness in adolescents and young adults, especially in obese youth. These data suggest that use of TG/HDL-C may be helpful in identifying young adults requiring aggressive intervention to prevent atherosclerotic CV diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.