ArticleCold Spring Harbor symposia on quantitative biology2012
Surprises from the chromosome front: lessons from Arabidopsis on telomeres and telomerase.
Article in Cold Spring Harbor symposia on quantitative biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- DDM1 guards against telomere truncation in Arabidopsis.Plant cell reports · 2018Article
- Dynamic Interactions of Arabidopsis TEN1: Stabilizing Telomeres in Response to Heat Stress.The Plant cell · 2016Article
- Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.PLoS genetics · 2014Article
- Extending the model of Arabidopsis telomere length and composition across Brassicaceae.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Article
- Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase.The Plant journal : for cell and molecular biology · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Telomeres serve two vital functions: They act as a buffer against the end-replication problem, and they prevent chromosome ends from being recognized as double-strand DNA (dsDNA) breaks. These functions are orchestrated by the telomerase reverse transcriptase and a variety of telomere protein complexes. Here, we discuss our recent studies with Arabidopsis thaliana that uncovered a new and highly conserved telomere complex called CST (Cdc13/CTC1, STN1, TEN1). Formerly believed to be yeast specific, CST has now been identified as a key component of both plant and vertebrate telomeres, which is essential for genome integrity and stem cell viability. We also describe the unexpected discovery of alternative telomerase ribonucleoprotein complexes in Arabidopsis. Fueled by duplication and diversification of the telomerase RNA subunit and telomerase accessory proteins, these telomerase complexes act in concert to maintain genome stability. In addition to the canonical telomerase enzyme, one of two alternative telomerase ribonucleoprotein (RNP) complexes functions as a novel negative regulator of enzyme activity in response to genotoxic stress. These contributions highlight the immense potential of Arabidopsis in probing the depths of the chromosome end.
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Registered trials
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