ArticleTechniques in coloproctology2013
Young colorectal carcinoma patients do not have a poorer prognosis: a comparative review of 2,426 cases.
Article in Techniques in coloproctology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed.
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- Early- vs. late-onset colon cancer: clinicopathological insights and survival outcomes in an East Asian cohort.International journal of colorectal disease · 2025Observational
- Comparative analysis of sporadic, IBD-associated, early-onset and late-onset colorectal cancer: a systematic review and meta-analysis.Therapeutic advances in gastroenterology · 2025Review
- Comparison of the short- and long-term prognosis of early-onset colorectal cancer compared with later-onset colorectal cancer: A systematic review and meta-analysis.Health science reports · 2023Article
- Colorectal Cancer in the Young: Research in Early Age Colorectal Cancer Trends (REACCT) Collaborative.Cancers · 2023Article
- A Retrospective Multicenter Study of the Clinicopathological Characteristics and Prognosis of Young Adult Patients with Colorectal Cancer: Effects of Chemotherapy on Prognosis.Journal of clinical medicine · 2023Article
- Article
- Reduced expression of alanyl aminopeptidase is a robust biomarker of non-familial adenomatous polyposis and non-hereditary nonpolyposis colorectal cancer syndrome early-onset colorectal cancer.Cancer medicine · 2023Article
- Article
- Correlation between mismatch repair statuses and the prognosis of stage I-IV colorectal cancer.Frontiers in oncology · 2023Article
- Clinicopathologic characteristics of early-onset colorectal cancer.Annals of coloproctology · 2022Article
- Early onset colorectal cancer: Challenges across the cancer care continuum.Annals of medicine and surgery (2012) · 2022Review
- Review
- Predictors of Lymph Node Metastasis in T1 Colorectal Cancer in Young Patients: Results from a National Cancer Registry.Journal of clinical medicine · 2021Article
- Preventive intraperitoneal hyperthermic perfusion chemotherapy for patients with T4 stage colon adenocarcinoma.Techniques in coloproctology · 2021Article
- Outcomes of young patients diagnosed with locally advanced rectal cancer.Journal of gastrointestinal oncology · 2021Article
- Early-onset colorectal cancer: initial clues and current views.Nature reviews. Gastroenterology & hepatology · 2020Review
- Inverse Association of Age with Risk of Lymph Node Metastasis in Superficial Colorectal Cancer: A Large Population-Based Study.The oncologist · 2020Article
- Nomogram predicting cancer-specific mortality in early-onset rectal cancer: a competing risk analysis.International journal of colorectal disease · 2020Article
- Age and Lymph Node Positivity in Patients With Colon and Rectal Cancer in the US Military Health System.Diseases of the colon and rectum · 2020Article
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Abstract
backgroundColorectal cancer (CRC) in "young" patients under 50 years of age is uncommon. There have been conflicting reports regarding both the clinicopathological features of CRC in young patients and prognosis. The aim of this study was to review and compare the clinical characteristics, prognostic factors, and overall survival of patients in three different age groups (40 years and under, 41-50 years, over 50 years of age) and the prognosis of these patients.
methodsA total of 2,426 consecutive patients who had undergone surgical resection for sporadic colorectal cancer at Singapore General Hospital in the period from 2000 to 2005 were retrieved from a prospectively collected computer database. There were 73 patients (3.0 %) in Group 1 (40 years old or less), 257 (10.6 %) in Group 2 (41-50 years old), and 2,096 (86.4 %) in Group 3 (>50 years old). Clinicopathological features were assessed using univariate analysis to evaluate significant differences, survival curves were constructed using the Kaplan-Meier method, and multivariate analysis was performed to evaluate the independent prognostic factors.
resultsYoung CRC patients tend to present with a higher incidence of mucinous and signet ring cell tumors (Group 1-20.5 %, Group 2-8.2 %, Group 3-6.2 %, p < 0.001) and have more poorly differentiated tumors (Group 1-20.0 %, Group 2-9.7 %, Group 3-7.4 %, p = 0.014). Furthermore, young CRC patients tend to present with regional lymph node metastases (Group 1-65.7 %, Group 2-60.8 %, Group 3-51.0 %, p = 0.001) and distant metastases (Group 1-31.5 %, Group 2-24.1 %, Group 3-19.4 %, p = 0.006). Multivariate analysis reveals, however, that young age is not an independent prognostic factor for cancer-specific survival (CSS) (p = 0.392). Five-year CSS for Group 1 was 56.6 % (95 % confidence interval (CI) 44.8-68.4 %), Group 2 53.8 % (95 % CI 47.3-60.3 %), and Group 3 61.1 % (95 % CI 58.9-63.3 %).
conclusionsAlthough presenting with advanced tumors and with poorer prognostic factors such as presence of mucin and poor histological differentiation, young CRC patients do not have a worse prognosis.
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