ArticleNeuro-oncology2013
Involved field radiation therapy after surgical resection of solitary brain metastases--mature results.
Article in Neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03285932 (Evaluation of Stereotactic Radiotherapy of the Resection Cavity After Surgery of Brain Metastases Compared to Post-operative Whole-brain Radiotherapy), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Evaluation of Stereotactic Radiotherapy of the Resection Cavity After Surgery of Brain Metastases Compared to Post-operative Whole-brain Radiotherapy
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Patients with single brain metastasis from non-small cell lung cancer equally benefit from stereotactic radiosurgery and surgery: a systematic review.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Brain metastases: Comparing clinical radiological differences in patients with lung and breast cancers treated with surgery.World neurosurgery: X · 2024Article
- Fractionated stereotactic radiotherapy of intracranial postoperative cavities after resection of brain metastases - Clinical outcome and prognostic factors.Clinical and translational radiation oncology · 2024Article
- Management of patients with brain metastases from NSCLC without a genetic driver alteration: upfront radiotherapy or immunotherapy?Therapeutic advances in medical oncology · 2023Review
- Different Expression and Clinical Implications of Cancer-Associated Fibroblast (CAF) Markers in Brain Metastases.Journal of Cancer · 2023Article
- The Debatable Benefit of Gross-Total Resection of Brain Metastases in a Comprehensive Treatment Setting.Cancers · 2021Article
- Adaptive radiosurgery based on two simultaneous dose prescriptions in the management of large renal cell carcinoma brain metastases in critical areas: Towards customization.Surgical neurology international · 2020Article
- Postoperative local fractionated radiotherapy for resected single brain metastases.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018Article
- Hypofractionated Radiation Therapy for Large Brain Metastases.Frontiers in oncology · 2018Review
- Combined FET PET/MRI radiomics differentiates radiation injury from recurrent brain metastasis.NeuroImage. Clinical · 2018Article
- Prolonged survival of patients with EGFR-mutated non-small cell lung cancer with solitary brain metastases treated with surgical resection of brain and lung lesions followed by EGFR TKIs.World journal of surgical oncology · 2017Article
- Treatment of brain oligometastases with hypofractionated stereotactic radiotherapy utilising volumetric modulated arc therapy.Clinical & experimental metastasis · 2016Article
- Resection Followed by Involved-Field Fractionated Radiotherapy in the Management of Single Brain Metastasis.Frontiers in oncology · 2015Article
- Stereotactic radiosurgery for treatment of brain metastases. A report of the DEGRO Working Group on Stereotactic Radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhole brain radiation therapy (WBRT) reduces local recurrence in patients after surgical resection of brain metastases without improving overall survival. Involved field radiation therapy (IFRT) has been used at our center to avoid delayed neurotoxicity associated with WBRT in well-selected patients with surgically resected single brain metastases. The purpose of this study was to evaluate the long-term outcomes of these patients.
methodsThirty-three consecutive patients with single brain metastases from a known primary tumor were treated with gross total resection followed by IFRT between 2006 and 2011. The postoperative surgical bed was treated to 40.05 Gy in 15 fractions of 2.67 Gy with conformal radiation therapy. Patients received serial MRIs and neurological exams in follow-up. Surgery, WBRT, or stereotactic radiosurgery was performed as salvage treatment when necessary.
resultsThe median follow-up was 16 months (range: 2-65 months). Local control, distant brain recurrence-free survival, and overall survival at 12 and 24 months were 90.3% and 85.8%, 60.7% and 51.4%, and 65.6% and 61.5%, respectively. Overall, 5 (15%) patients developed recurrence at the resection cavity, and 13 (39%) patients experienced recurrence at a new intracranial site. Two patients received WBRT, 8 stereotactic radiosurgery, 2 surgery, and 2 both chemotherapy and IFRT as salvage. Four patients died from CNS disease progression.
conclusionFor patients with newly diagnosed single brain metastases treated with surgical resection, postoperative IFRT to the resection cavity achieves reasonable rates of local control and is an excellent alternative to WBRT.
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