ArticleHippocampus2013
Sexual experience restores age-related decline in adult neurogenesis and hippocampal function.
Article in Hippocampus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Modifying Factors of Adult Hippocampal Neurogenesis: A Dorsoventral Perspective in Health and Disease.Cells · 2025Review
- Neural stem cell heterogeneity in adult hippocampus.Cell regeneration (London, England) · 2025Review
- Mating-induced neurogenesis and cell proliferation in male rats depend on opioid signaling.PloS one · 2025Article
- Neurocognitive effects of stress: a metaparadigm perspective.Molecular psychiatry · 2023Review
- Does activation of oxytocinergic reward circuits postpone the decline of the aging brain?Frontiers in psychology · 2023Review
- Neuroplastic changes in c-Fos, ΔFosB, BDNF, trkB, and Arc expression in the hippocampus of male Roman rats: differential effects of sexual activity.Hippocampus · 2022Article
- Effects of pairing on color change and central gene expression in lined seahorses.Genes, brain, and behavior · 2022Article
- Pair-bonding and social experience modulate new neurons survival in adult male and female prairie voles (Frontiers in neuroanatomy · 2022Article
- Adult Neurogenesis: A Story Ranging from Controversial New Neurogenic Areas and Human Adult Neurogenesis to Molecular Regulation.International journal of molecular sciences · 2021Review
- Chemogenetic inhibition of prefrontal projection neurons constrains top-down control of attention in young but not aged rats.Brain structure & function · 2021Article
- Review
- Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence.Frontiers in behavioral neuroscience · 2020Review
- The neural and genetic correlates of satisfying sexual activity in heterosexual pair-bonds.Brain and behavior · 2019Article
- Adult Neurogenesis, Glia, and the Extracellular Matrix.Cell stem cell · 2019Review
- Sexual activity modulates neuroinflammatory responses in male rats.Physiology & behavior · 2018Article
- Sexual interactions with unfamiliar females reduce hippocampal neurogenesis among adult male rats.Neuroscience · 2016Article
- Sexual Stimulation Increases the Survival of New Cells in the Accessory Olfactory Bulb of the Male Rat.Frontiers in neuroscience · 2016Article
- Activity Dependency and Aging in the Regulation of Adult Neurogenesis.Cold Spring Harbor perspectives in biology · 2015Review
- Molecular mechanisms underlying the memory-enhancing effects of estradiol.Hormones and behavior · 2015Review
- Novel functions of GABA signaling in adult neurogenesis.Frontiers in biology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Aging is associated with compromised hippocampal function and reduced adult neurogenesis in the dentate gyrus. As new neurons have been linked to hippocampal functions, such as cognition, age-related decline in new neuron formation may contribute to impaired hippocampal function. We investigated whether a rewarding experience known to stimulate neurogenesis in young adult rats, namely sexual experience, would restore new neuron production and hippocampal function in middle-aged rats. Sexual experience enhanced the number of newly generated neurons in the dentate gyrus with both single and repeated exposures in middle-aged rats. Following continuous long-term exposure to sexual experience, cognitive function was improved. However, when a prolonged withdrawal period was introduced between the final mating experience and behavioral testing, the improvements in cognitive function were lost despite the presence of more new neurons. Taken together, these results suggest that repeated sexual experience can stimulate adult neurogenesis and restore cognitive function in the middle-aged rat as long as the experience persists throughout the testing period. The extent to which changes in adult neurogenesis underlie those in cognition remain unknown.
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Registered trials
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