ArticleFrontiers in psychiatry2013
Molecular Neurobiology of Depression: PET Findings on the Elusive Correlation with Symptom Severity.
Article in Frontiers in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Impact of Inflammation on White Matter Integrity and Functional Connectivity in Chronic Major Depressive Disorder.Biological psychiatry · 2026Article
- Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Pathophysiology and Current Drug Treatments for Post-Stroke Depression: A Review.International journal of molecular sciences · 2022Review
- Translational application of neuroimaging in major depressive disorder: a review of psychoradiological studies.Frontiers of medicine · 2021Review
- Predicting Treatment Outcome in Major Depressive Disorder Using Serotonin 4 Receptor PET Brain Imaging, Functional MRI, Cognitive-, EEG-Based, and Peripheral Biomarkers: A NeuroPharm Open Label Clinical Trial Protocol.Frontiers in psychiatry · 2020Article
- The rise and fall of MRI studies in major depressive disorder.Translational psychiatry · 2019Review
- Regulatory Pathways of Monoamine Oxidase A during Social Stress.Frontiers in neuroscience · 2017Review
- An excitatory synapse hypothesis of depression.Trends in neurosciences · 2015Review
- Role of peripheral vascular resistance for the association between major depression and cardiovascular disease.Journal of cardiovascular pharmacology · 2015Review
- Imaging the pathophysiology of major depressive disorder - from localist models to circuit-based analysis.Biology of mood & anxiety disorders · 2014Article
- Circadian rhythms and mood: opportunities for multi-level analyses in genomics and neuroscience: circadian rhythm dysregulation in mood disorders provides clues to the brain's organizing principles, and a touchstone for genomics and neuroscience.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Ketamine as antidepressant? Current state and future perspectives.Current neuropharmacology · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Molecular mechanisms in the brain are assumed to cause the symptoms and severity of neuropsychiatric disorders. This review concerns the elusive nature of relationships between the severity of depressive disorders and neuromolecular processes studied by positron emission tomography (PET). Recent PET studies of human depression have focused on serotonergic, dopaminergic, muscarinic, nicotinic, and GABAergic receptors, as well as central processes dependent on monoamine oxidase, phosphodiesterase type 4, amyloid plaques, neurofibrillar tangles, and P-glycoprotein. We find that reliable causal links between neuromolecular mechanisms and relief from depressive disorders have yet to be convincingly demonstrated. This situation may contribute to the currently limited use of PET for exploring the neuropathways that are currently viewed as being responsible for beneficial effects of antidepressant treatment regimes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.