ArticleNeuropsychiatric disease and treatment2013
Postpartum depression: psychoneuroimmunological underpinnings and treatment.
Article in Neuropsychiatric disease and treatment, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02566980 (The Role of Kynurenine Pathway Metabolites in Perinatal Depression and Suicidality), which is not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Kynurenine Pathway Metabolites in Perinatal Depression and Suicidality
Who cites it
30 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- Considering the role of estradiol in the psychoneuroimmunology of perimenopausal depression.Brain, behavior, & immunity - health · 2024Article
- Postnatal Development of the Circadian Rhythmicity of Human Pineal Melatonin Synthesis and Secretion (Systematic Review).Children (Basel, Switzerland) · 2024Review
- Molecular basis underlying default mode network functional abnormalities in postpartum depression with and without anxiety.Human brain mapping · 2024Article
- Biomarkers of Postpartum Depression: A Narrative Review.Journal of clinical medicine · 2023Review
- Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats.Neurobiology of stress · 2023Article
- The Cytokine, Chemokine, and Growth Factor Network of Prenatal Depression.Brain sciences · 2023Article
- Postpartum depression in rats causes poor maternal care and neurochemical alterations on dams and long-lasting impairment in sociability on the offspring.Behavioural brain research · 2023Article
- Mitochondrial might: powering the peripartum for risk and resilience.Frontiers in behavioral neuroscience · 2023Review
- Mangiferin Alleviates Postpartum Depression-Like Behaviors by Inhibiting MAPK Signaling in Microglia.Frontiers in pharmacology · 2022Article
- Migraine associated with early onset postpartum depression in women with major depressive disorder.Archives of women's mental health · 2021Article
- Pregnancy-Related Weight and Postpartum Depressive Symptoms: Do the Relationships Differ by Race/Ethnicity?Journal of women's health (2002) · 2021Article
- The Importance of Screening in Prevention of Postpartum Depression.Iranian journal of public health · 2021Article
- Postpartum depression and mother-offspring conflict over maternal investment.Evolution, medicine, and public health · 2021Article
- Genetic Polymorphism of rs13306146 AffectsFrontiers in genetics · 2021Article
- Postpartum Depression: Current Status and Possible Identification Using Biomarkers.Frontiers in psychiatry · 2021Review
- Biological reflect of Adiponectin hormone in postpartum marital satisfaction and depression scores.BMC pregnancy and childbirth · 2020Article
- PPAR and functional foods: Rationale for natural neurosteroid-based interventions for postpartum depression.Neurobiology of stress · 2020Article
- Pregnancy, postpartum and parity: Resilience and vulnerability in brain health and disease.Frontiers in neuroendocrinology · 2020Review
- Correlations BetweenNeuropsychiatric disease and treatment · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postpartum depression (PPD) is common, occurring in 10%-15% of women. Due to concerns about teratogenicity of medications in the suckling infant, the treatment of PPD has often been restricted to psychotherapy. We review here the biological underpinnings to PPD, suggesting a powerful role for the tryptophan catabolites, indoleamine 2,3-dixoygenase, serotonin, and autoimmunity in mediating the consequences of immuno-inflammation and oxidative and nitrosative stress. It is suggested that the increased inflammatory potential, the decreases in endogenous anti-inflammatory compounds together with decreased omega-3 poly-unsaturated fatty acids, in the postnatal period cause an inflammatory environment. The latter may result in the utilization of peripheral inflammatory products, especially kynurenine, in driving the central processes producing postnatal depression. The pharmacological treatment of PPD is placed in this context, and recommendations for more refined and safer treatments are made, including the better utilization of the antidepressant, and the anti-inflammatory and antioxidant effects of melatonin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.