Evidence map›Paper›PMID 23459459›Full record

ArticleTopics in spinal cord injury rehabilitation2012

Effects of nicotine on spinal cord injury pain: a randomized, double-blind, placebo controlled crossover trial.

Elizabeth J Richardson, J Scott Richards, Christopher C Stewart, Timothy J Ness

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Topics in spinal cord injury rehabilitation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Guideline
  2. Development of a pain self-management intervention framework for people with spinal cord injury.African journal of primary health care & family medicine · 2023
    Article
  3. Article
  4. Article
  5. Review
  6. Evaluation and Management of SCI-Associated Pain.Current pain and headache reports · 2016
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Elizabeth J RichardsonDepartment of Physical Medicine and Rehabilitation , University of Alabama at Birmingham, Birmingham, Alabama.
J Scott Richards
Christopher C Stewart
Timothy J Ness
University of Alabama at Birmingham · USMedical College of Wisconsin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOne factor affecting spinal cord injury (SCI)-related pain may be nicotine. Case reports have described a worsening of neuropathic pain from smoking and relief from abstinence. Neurobiological correlates also implicate the potential effect of nicotine on SCI-related pain.

methodThe current study employed a randomized, placebo-controlled crossover design to examine the effect of nicotine exposure on subtypes of SCI-related pain among smokers and nonsmokers.

resultsWhereas nonsmokers with SCI showed a reduction in mixed forms of pain following nicotine exposure, smokers with SCI showed a converse increase in pain with regard to both mixed and neuropathic forms of pain. The exacerbation of pain in chronic nicotine or tobacco users may not only elucidate possible pain mechanisms but may also be of use in smoking cessation counseling among those with SCI.

Indexed as

neuropathic painnicotinepainrandomized controlled trialsmokingspinal cord injury

Identifiers

PMID23459459
PMCPMC3584761
OpenAlexW2036988856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.