ArticleAmerican journal of cardiovascular disease2013
Bifurcation theory and cardiac arrhythmias.
Article in American journal of cardiovascular disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Optical Ultrastructure of Large Mammalian Hearts Recovers Discordant Alternans byFrontiers in network physiology · 2022Article
- Cardiac Alternans Occurs through the Synergy of Voltage- and Calcium-Dependent Mechanisms.Membranes · 2021Article
- Simulating Notch-Dome Morphology of Action Potential of Ventricular Cell: How the Speeds of Positive and Negative Feedbacks on Transmembrane Voltage Can Influence the Health of a Cell?BioMed research international · 2020Article
- Dynamics of spatiotemporal line defects and chaos control in complex excitable systems.Scientific reports · 2017Article
- Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets.Frontiers in pharmacology · 2017Review
- Predicting the risk of sudden cardiac death.The Journal of physiology · 2016Review
- Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics.The Journal of physiology · 2016Article
- Article
- The virtual heart as a platform for screening drug cardiotoxicity.British journal of pharmacology · 2015Review
- From Incidental, Mechanically-Induced Arrhythmias to Reflex-Defined Arrhythmogenicity: On The Track of The Ternary Reflex System Resemblance to The "Infancy" of New Era or Rediscovery.Journal of atrial fibrillationReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In this paper we review two types of dynamic behaviors defined by the bifurcation theory that are found to be particularly useful in describing two forms of cardiac electrical instabilities that are of considerable importance in cardiac arrhythmogenesis. The first is action potential duration (APD) alternans with an underlying dynamics consistent with the period doubling bifurcation theory. This form of electrical instability could lead to spatially discordant APD alternans leading to wavebreak and reentrant form of tachyarrhythmias. Factors that modulate the APD alternans are discussed. The second form of bifurcation of importance to cardiac arrhythmogenesis is the Hopf-homoclinic bifurcation that adequately describes the dynamics of the onset of early afterdepolarization (EAD)-mediated triggered activity (Hopf) that may cause ventricular tachycardia and ventricular fibrillation (VT/VF respectively). The self-termination of the triggered activity is compatible with the homoclinic bifurcation. Ionic and intracellular calcium dynamics underlying these dynamics are discussed using available experimental and simulation data. The dynamic analysis provides novel insights into the mechanisms of VT/VF, a major cause of sudden cardiac death in the US.
Indexed as
Identifiers
23459417PMC3584649W1538188928What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.