ArticlePLoS neglected tropical diseases2013
An integrated linkage, chromosome, and genome map for the yellow fever mosquito Aedes aegypti.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 58 citations in OpenAlex.
- Vector competence acrossJournal of virology · 2026Review
- Insights on the sex determination, vector capacity and ecological biology from a chromosomal level genome of vector mosquito, Armigeres subulbatus.Infectious diseases of poverty · 2025Article
- Chromosomal Inversions and Their Potential Impact on the Evolution of Arboviral Vector Aedes aegypti.Genome biology and evolution · 2025Article
- In Silico Characterisation of theInternational journal of molecular sciences · 2023Article
- A DBHS family member regulates male determination in the filariasis vector Armigeres subalbatus.Nature communications · 2023Article
- Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues.Nature communications · 2023Article
- A chromosome-level assembly of the widely used Rockefeller strain of Aedes aegypti, the yellow fever mosquito.G3 (Bethesda, Md.) · 2022Article
- Introgression of theFrontiers in bioengineering and biotechnology · 2022Article
- Transcriptomic and proteomic analysis of pyrethroid resistance in the CKR strain of Aedes aegypti.PLoS neglected tropical diseases · 2021Article
- Genetic sexing strains for the population suppression of the mosquito vectorPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Article
- Irradiation induced inversions suppress recombination between the M locus and morphological markers in Aedes aegypti.BMC genetics · 2020Article
- Improved reference genome of the arboviral vector Aedes albopictus.Genome biology · 2020Article
- Chromatin Structure and Function in Mosquitoes.Frontiers in genetics · 2020Review
- Germline-Specific Repetitive Elements in Programmatically Eliminated Chromosomes of the Sea Lamprey (Genes · 2019Article
- Vgsc-interacting proteins are genetically associated with pyrethroid resistance in Aedes aegypti.PloS one · 2019Article
- Article
- The effect of parasite infection on the recombination rate of the mosquito Aedes aegypti.PloS one · 2018Article
- Deep ancestry of programmed genome rearrangement in lampreys.Developmental biology · 2017Article
- Extensive Genetic Differentiation between Homomorphic Sex Chromosomes in the Mosquito Vector, Aedes aegypti.Genome biology and evolution · 2017Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAedes aegypti, the yellow fever mosquito, is an efficient vector of arboviruses and a convenient model system for laboratory research. Extensive linkage mapping of morphological and molecular markers localized a number of quantitative trait loci (QTLs) related to the mosquito's ability to transmit various pathogens. However, linking the QTLs to Ae. aegypti chromosomes and genomic sequences has been challenging because of the poor quality of polytene chromosomes and the highly fragmented genome assembly for this species. METHODOLOGY/PRINCIPAL
findingsBased on the approach developed in our previous study, we constructed idiograms for mitotic chromosomes of Ae. aegypti based on their banding patterns at early metaphase. These idiograms represent the first cytogenetic map developed for mitotic chromosomes of Ae. aegypti. One hundred bacterial artificial chromosome clones carrying major genetic markers were hybridized to the chromosomes using fluorescent in situ hybridization. As a result, QTLs related to the transmission of the filarioid nematode Brugia malayi, the avian malaria parasite Plasmodium gallinaceum, and the dengue virus, as well as sex determination locus and 183 Mbp of genomic sequences were anchored to the exact positions on Ae. aegypti chromosomes. A linear regression analysis demonstrated a good correlation between positions of the markers on the physical and linkage maps. As a result of the recombination rate variation along the chromosomes, 12 QTLs on the linkage map were combined into five major clusters of QTLs on the chromosome map.
conclusionThis study developed an integrated linkage, chromosome, and genome map-iMap-for the yellow fever mosquito. Our discovery of the localization of multiple QTLs in a few major chromosome clusters suggests a possibility that the transmission of various pathogens is controlled by the same genomic loci. Thus, the iMap will facilitate the identification of genomic determinants of traits responsible for susceptibility or refractoriness of the mosquito to diverse pathogens.
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