ReviewBrain, behavior, and immunity2013
Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger.
Review in Brain, behavior, and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
74 citing papers in PubMed, 157 citations in OpenAlex.
- Active coping mitigates the effects of stress on glucocorticoid levels in the prefrontal cortex.Brain, behavior, and immunity · 2025Article
- Single-Nucleus RNA Sequencing Reveals Enduring Signatures of Acute Stress and Chronic Exercise in Striatal Microglia.Genes, brain, and behavior · 2025Article
- Article
- Prefrontal projections to the bed nuclei of the stria terminalis modulate the specificity of aversive memories.Research square · 2024Article
- Article
- Chronic ethanol induces a pro-inflammatory switch in interleukin-1β regulation of GABAergic signaling in the medial prefrontal cortex of male mice.Brain, behavior, and immunity · 2023Article
- Sex differences in depression: An immunological perspective.Brain research bulletin · 2023Review
- Oral CBD-rich hemp extract modulates sterile inflammation in female and male rats.Frontiers in physiology · 2023Article
- The effect of oxytocin and an enriched environment on anxiety-like behaviour and corticosterone levels in a prenatally stressed febrile seizure rat model.IBRO neuroscience reports · 2022Article
- Activity in a prefrontal-periaqueductal gray circuit overcomes behavioral and endocrine features of the passive coping stress response.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Blood levels of T-Cell Receptor Excision Circles (TRECs) provide an index of exposure to traumatic stress in mice and humans.Translational psychiatry · 2022Article
- The Role of Microglia in the (Mal)adaptive Response to Traumatic Experience in an Animal Model of PTSD.International journal of molecular sciences · 2022Article
- Article
- An evaluation of the rat intestinal monoamine biogeography days following exposure to acute stress.Frontiers in physiology · 2022Article
- Whey Protein Supplementation Effects on Body Composition, Performance, and Blood Biomarkers During Army Initial Entry Training.Frontiers in nutrition · 2022Article
- Hypothalamic-Pituitary-End-Organ Axes: Hormone Function in Female Patients with Major Depressive Disorder.Neuroscience bulletin · 2021Review
- Light at night during development in mice has modest effects on adulthood behavior and neuroimmune activation.Behavioural brain research · 2021Article
- A Decision Architecture for Safety Computations.Trends in cognitive sciences · 2021Review
- Neurobiology of resilience in depression: immune and vascular insights from human and animal studies.The European journal of neuroscience · 2021Review
- Blood Will Tell: What Hematological Analyses Can Reveal About Fish Welfare.Frontiers in veterinary science · 2021Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A considerable number of studies demonstrate that acute and chronic stressors prime CNS innate immune responses to subsequent pro-inflammatory challenges and that glucocorticoids mediate, in part, stress-induced sensitization of pro-inflammatory immune responses. Here, we explore the notion that GCs produce a persisting sensitization of CNS innate immune effectors (e.g. microglia) so that they will generate a potentiated pro-inflammatory response after the GC rise has dissipated, thereby enhancing the sickness response to infection or injury and maximizing the animal's ability to neutralize danger. The stress-induced GC response is conceptualized here as an neuroendocrine warning signal or alarmin to the innate immune system, which prepares or sensitizes the innate immune response to potential danger. Thus, a new understanding of the stress response and its function (priming CNS innate immune responses to infection or injury during a fight/flight emergency) would be suggested.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.