ReviewNeuroscience and biobehavioral reviews2013
Moment-to-moment brain signal variability: a next frontier in human brain mapping?
Review in Neuroscience and biobehavioral reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 307 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
307 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Within-Individual BOLD Signal Variability and its Implications for Task-Based Cognition: A Systematic Review.Neuropsychology review · 2024Pooled it
- Systematic Review and Meta-Analysis: Do White Noise or Pink Noise Help With Task Performance in Youth With Attention-Deficit/Hyperactivity Disorder or With Elevated Attention Problems?Journal of the American Academy of Child and Adolescent Psychiatry · 2024Pooled it
- Prefrontal, parietal, and limbic condition-dependent differences in bipolar disorder: a large-scale meta-analysis of functional neuroimaging studies.Molecular psychiatry · 2023Pooled it
- Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- High-definition tDCS over primary motor cortex modulates brain signal variability and functional connectivity in episodic migraine.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Trial
- Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.Neuromodulation : journal of the International Neuromodulation Society · 2023Trial
- Dynamic Recovery: GABA Agonism Restores Neural Variability in Older, Poorer Performing Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Trial
- Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity.Scientific reports · 2021Trial
- Brain signal variability during rest as a neural mechanism underlying cognitive reserve.NeuroImage · 2026Article
- Beyond the General Linear Model: Linear Mixed-Effects Modeling of fMRI Data from the Human Connectome Project.Neuroinformatics · 2026Article
- The mediating effect of neuroticism on the association between brain signal variability in the prefrontal cortex and depression among healthy individuals.Brain imaging and behavior · 2026Article
- Dynamic Hemispheric Lateralization of Naturalistic Emotional Processing After Unilateral Stroke: An EEG Study.CNS neuroscience & therapeutics · 2026Article
- Protracted Maturation of Proactive and Reactive Systems Predicts Cognitive Stability and Psychopathology : A longitudinal multi-cohort study.bioRxiv : the preprint server for biology · 2026Article
- Cognitive Processing and EEG Complexity.Entropy (Basel, Switzerland) · 2026Review
- Alpha Frequency Dysrhythmia in Treatment-Resistant Schizophrenia: Associations with EEG Background Changes, Disorganized Symptoms, and Dissociation.Biomedicines · 2026Article
- Sharp-Wave EEG Activity and Cytomegalovirus Exposure in Schizophrenia Spectrum Disorders: A Neuroimmune Perspective.Journal of clinical medicine · 2026Article
- Perceptual Decision Efficiency and Optimal Sleep Quality Are Associated with Female College Soccer Injury Avoidance.Brain sciences · 2026Article
- Cognitive-Behavioral Predictors of Individual Variability of Functional Connectivity in Healthy Young Adults.Research square · 2026Article
- Neural variability across the transition to motherhood: Enhanced moment-to-moment neural variability during mentalizing in first-time mothers.Journal of neuroendocrinology · 2026Article
- Trial-By-Trial Changes in Neural Indices of Performance Monitoring Uniquely Correspond to Behavioral Adjustments During a Flanker Task.Human brain mapping · 2026Article
247 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Neuroscientists have long observed that brain activity is naturally variable from moment-to-moment, but neuroimaging research has largely ignored the potential importance of this phenomenon. An emerging research focus on within-person brain signal variability is providing novel insights, and offering highly predictive, complementary, and even orthogonal views of brain function in relation to human lifespan development, cognitive performance, and various clinical conditions. As a result, brain signal variability is evolving as a bona fide signal of interest, and should no longer be dismissed as meaningless noise when mapping the human brain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.