Evidence map›Paper›PMID 23458756›Full record

ArticleEnvironmental health perspectives2013

The broad scope of health effects from chronic arsenic exposure: update on a worldwide public health problem.

Marisa F Naujokas, Beth Anderson, Habibul Ahsan, H Vasken Aposhian, Joseph H Graziano, Claudia Thompson, William A Suk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 490 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
490citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

490 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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430 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marisa F NaujokasMDB Inc., Durham, North Carolina 27713, USA. naujokasmf@niehs.nih.gov
Beth Anderson
Habibul Ahsan
H Vasken Aposhian
Joseph H Graziano
Claudia Thompson
William A Suk

Funding

Training CoreP42ES010349 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAVAS-ACIEN, ANA · 2000 to 2020
$53.6M
Chemoprevention of arsenic-induced skin cancerR01CA107431 · NCI · UNIVERSITY OF CHICAGO · PI AHSAN, HABIBUL · 2005 to 2014
$17.3M
Genetic Susceptibility to Arsenic-induced Skin CancerR01CA102484 · NCI · UNIVERSITY OF CHICAGO · PI AHSAN, HABIBUL · 2004 to 2008
$2.0M
NCI NIH HHS R01 CA102484NCI NIH HHS R01CA102484NCI NIH HHS R01 CA107431NCI NIH HHS R01CA107431NIEHS NIH HHS P42 ES010349NIEHS NIH HHS P42ES10349
6 · The paper itself

Abstract

backgroundConcerns for arsenic exposure are not limited to toxic waste sites and massive poisoning events. Chronic exposure continues to be a major public health problem worldwide, affecting hundreds of millions of persons.

objectivesWe reviewed recent information on worldwide concerns for arsenic exposures and public health to heighten awareness of the current scope of arsenic exposure and health outcomes and the importance of reducing exposure, particularly during pregnancy and early life.

methodsWe synthesized the large body of current research pertaining to arsenic exposure and health outcomes with an emphasis on recent publications. DISCUSSION: Locations of high arsenic exposure via drinking water span from Bangladesh, Chile, and Taiwan to the United States. The U.S. Environmental Protection Agency maximum contaminant level (MCL) in drinking water is 10 µg/L; however, concentrations of > 3,000 µg/L have been found in wells in the United States. In addition, exposure through diet is of growing concern. Knowledge of the scope of arsenic-associated health effects has broadened; arsenic leaves essentially no bodily system untouched. Arsenic is a known carcinogen associated with skin, lung, bladder, kidney, and liver cancer. Dermatological, developmental, neurological, respiratory, cardiovascular, immunological, and endocrine effects are also evident. Most remarkably, early-life exposure may be related to increased risks for several types of cancer and other diseases during adulthood.

conclusionsThese data call for heightened awareness of arsenic-related pathologies in broader contexts than previously perceived. Testing foods and drinking water for arsenic, including individual private wells, should be a top priority to reduce exposure, particularly for pregnant women and children, given the potential for life-long effects of developmental exposure.

Indexed as

Public HealthArsenicDrinking WaterEnvironmental PollutantsHumansUnited StatesUnited States Environmental Protection AgencyArsenicDrinking WaterEnvironmental Pollutants

Identifiers

PMID23458756
PMCPMC3621177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.