Evidence map›Paper›PMID 23458718›Full record

ReviewJournal of anatomy2014

The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis.

Inga Koneczny, Judith Cossins, Angela Vincent

Open access · greenAbstract readReview
In one paragraph

Review in Journal of anatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Therapeutic advances of targeting receptor tyrosine kinases in cancer.Signal transduction and targeted therapy · 2024
    Review
  3. Article
  4. Review
  5. Antibody Therapies in Autoimmune Neuromuscular Junction Disorders: Approach to Myasthenic Crisis and Chronic Management.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  6. Observational
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Autoimmune Thyroiditis and Myasthenia Gravis.Frontiers in endocrinology · 2017
    Review
  16. Muscle-Specific Receptor Tyrosine Kinase (MuSK) Myasthenia Gravis.Current neurology and neuroscience reports · 2016
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Inga KonecznyNeurosciences Group, Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Judith Cossins
Angela Vincent
MRC Weatherall Institute of Molecular Medicine · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MuSK myasthenia gravis is a rare, severe autoimmune disease of the neuromuscular junction, only identified in 2001, with unclear pathogenic mechanisms. In this review we describe the clinical aspects that distinguish MuSK MG from AChR MG, review what is known about the role of MuSK in the development and function of the neuromuscular junction, and discuss the data that address how the antibodies to MuSK lead to neuromuscular transmission failure.

Indexed as

AutoantibodiesHumansMyasthenia GravisNeuromuscular JunctionReceptor Protein-Tyrosine KinasesReceptors, CholinergicAutoantibodiesMUSK protein, humanReceptor Protein-Tyrosine KinasesReceptors, CholinergicAChRDOK7IgG4LRP4MGmuscle-specific tyrosine kinasemyasthenia gravisneuromuscular transmissionquantal contentRAPSN

Identifiers

PMID23458718
PMCPMC3867884
OpenAlexW2071737672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.