Observational studyHPB : the official journal of the International Hepato Pancreato Biliary Association2013
Triple approach strategy for patients with locally advanced pancreatic carcinoma.
Observational study in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Assessment of Ablation Therapy in Pancreatic Cancer: The Radiologist's Challenge.Frontiers in oncology · 2020Pooled it
- Systematic review of minimally invasive ablation treatment for locally advanced pancreatic cancer.La Radiologia medica · 2014Pooled it
- Systematic review of novel ablative methods in locally advanced pancreatic cancer.World journal of gastroenterology · 2014Pooled it
- EUS-Guided Radiofrequency Ablation Therapy for Pancreatic Neoplasia.Diagnostics (Basel, Switzerland) · 2024Review
- Locoregional Therapies and Remodeling of Tumor Microenvironment in Pancreatic Cancer.International journal of molecular sciences · 2023Review
- Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives.Life (Basel, Switzerland) · 2023Review
- Endoscopic Ultrasound-Guided Laser Ablation Using a Diffusing Applicator for Locally Advanced Pancreatic Cancer Treatment.Cancers · 2022Article
- Benefitial role of electrochemotherapy in locally advanced pancreatic cancer - radiological perspective.Polish journal of radiology · 2022Review
- Role of endoscopic ultrasound in anticancer therapy: Current evidence and future perspectives.World journal of gastrointestinal oncology · 2021Review
- Role of radio-ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review).Experimental and therapeutic medicine · 2021Review
- Minimally invasive image-guided therapy of primary and metastatic pancreatic cancer.World journal of gastroenterology · 2021Review
- Local ablation of pancreatic tumors: State of the art and future perspectives.World journal of gastroenterology · 2021Review
- Article
- Review
- Role of Radiofrequency Ablation in the Management of Unresectable Pancreatic Cancer.Frontiers in medicine · 2020Review
- Technique, safety, and feasibility of EUS-guided radiofrequency ablation in unresectable pancreatic cancer.Surgical endoscopy · 2018Article
- Review
- Palliative therapy in pancreatic cancer-interventional treatment with radiofrequency ablation/irreversible electroporation.Translational gastroenterology and hepatology · 2018Review
- Role of local ablative techniques (Radiofrequency ablation and Irreversible Electroporation) in the treatment of pancreatic cancer.Updates in surgery · 2016Review
- Variation of tumoral marker after radiofrequency ablation of pancreatic adenocarcinoma.Journal of gastrointestinal oncology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiofrequency ablation (RFA) is a relatively new technique, applied to metastatic solid tumours which, in recent studies, has been shown to be feasible and safe on locally advanced pancreatic carcinoma (LAPC). RFA can be combined with radio-chemotherapy (RCT) and intra-arterial plus systemic chemotherapy (IASC). The aim of this study was to investigate the impact on the prognosis of a multimodal approach to LAPC and define the best timing of RFA.
methodsThis is a retrospective observational study of patients who have consecutively undergone RFA associated with multiple adjuvant approaches.
resultsBetween February 2007 and December 2011, 168 consecutive patients were treated by RFA, of which 107 were eligible for at least 18 months of follow-up. Forty-seven patients (group 1) underwent RFA as an up-front treatment and 60 patients as second treatment (group 2) depending on clinician choice. The median overall survival (OS) of the whole series was 25.6 months: 14.7 months in the group 1 and 25.6 months in the group 2 (P = 0.004). Those patients who received the multimodal treatment (RFA, RCT and IASC-triple approach strategy) had an OS of 34.0 months.
conclusionsThe multimodal approach seems to be feasible and associated with an improved longer survival rate.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.