ReviewNeuropharmacology2014
PET studies in nonhuman primate models of cocaine abuse: translational research related to vulnerability and neuroadaptations.
Review in Neuropharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- The impact of sex, species, environmental context, and alternative reinforcers in animal models of cocaine use disorders.Pharmacology, biochemistry, and behavior · 2025Review
- Convergent and divergent neural and behavioral responses to chronic cocaine use in macaques.bioRxiv : the preprint server for biology · 2025Article
- Acquisition of cocaine reinforcement using fixed-ratio and concurrent choice schedules in socially housed female and male monkeys.Psychopharmacology · 2024Article
- Neuron Navigator 1 (Nav1) regulates the response to cocaine in mice.Communications biology · 2023Article
- Cannabis users demonstrate enhanced neural reactivity to reward: An event-related potential and time-frequency EEG study.Addictive behaviors · 2021Article
- Personality Traits or Genetic Determinants-Which Strongly Influences E-Cigarette Users?International journal of environmental research and public health · 2020Article
- Nonhuman animal models of substance use disorders: Translational value and utility to basic science.Drug and alcohol dependence · 2020Review
- Neuroimaging of reward mechanisms in Gambling disorder: an integrative review.Molecular psychiatry · 2019Review
- Dopamine and addiction: what have we learned from 40 years of research.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2018Article
- Addiction and Dopamine: Sex Differences and Insights from Studies of Smoking.Current opinion in behavioral sciences · 2018Article
- Article
- High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens.Neuroscience letters · 2018Article
- Utility of Nonhuman Primates in Substance Use Disorders Research.ILAR journal · 2017Review
- Longitudinal Changes in Brain Metabolic Activity after Withdrawal from Escalation of Cocaine Self-Administration.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Synaptic mechanisms underlying persistent cocaine craving.Nature reviews. Neuroscience · 2016Review
- Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates.Psychopharmacology · 2016Article
- Emergence of sex differences in the development of substance use and abuse during adolescence.Pharmacology & therapeutics · 2015Review
- Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.Journal of medicinal chemistry · 2015Article
- Biological substrates of addiction.Wiley interdisciplinary reviews. Cognitive science · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The current review highlights the utility of positron emission tomography (PET) imaging to study the neurobiological substrates underlying vulnerability to cocaine addiction and subsequent adaptations following chronic cocaine self-administration in nonhuman primate models of cocaine abuse. Environmental (e.g., social rank) and sex-specific influences on dopaminergic function and sensitivity to the reinforcing effects of cocaine are discussed. Cocaine-related cognitive deficits have been hypothesized to contribute to high rates of relapse and are described in nonhuman primate models. Lastly, the long-term consequences of cocaine on neurobiology are discussed. PET imaging and longitudinal, within-subject behavioral studies in nonhuman primates have provided a strong framework for designing pharmacological and behavioral treatment strategies to aid drug-dependent treatment seekers. Non-invasive PET imaging will allow for individualized treatment strategies. Recent advances in radiochemistry of novel PET ligands and other imaging modalities can further advance our understanding of stimulant use on the brain. This article is part of the Special Issue Section entitled 'Neuroimaging in Neuropharmacology'.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.