SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2013
Review of the investigation and surgical management of resectable ampullary adenocarcinoma.
Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- miR-216 Is a Key Regulator and Potential Marker in Human Cancers.Advanced biomedical research · 2025Review
- Pushing the Boundaries of Ampullectomy for Benign Ampullary Tumors: 25-Year Outcomes of Surgical Ampullary Resection Associated with Duodenectomy or Biliary Resection.Journal of clinical medicine · 2024Article
- Pancreatic head resection for carcinoma of the ampulla vateri - better long-term prognosis, but more postoperative complications.Langenbeck's archives of surgery · 2024Article
- Article
- Clinical outcomes of endoscopic papillectomy of ampullary adenoma: A multi-center study.World journal of gastroenterology · 2022Article
- Adenomatous neoplasia in the papilla of Vater endoscopic and/or surgical resection?Surgical endoscopy · 2022Article
- Ampullary carcinoma of the duodenum: current clinical issues and genomic overview.Surgery today · 2022Review
- Survival after curative pancreaticoduodenectomy for ampullary adenocarcinoma in a South American population: A retrospective cohort study.World journal of gastrointestinal surgery · 2022Article
- Predictors and Recurrence Patterns After Radical Surgery in Ampulla of Vater Cancer: Comparative Analysis Between Early and Late Recurrence.Frontiers in surgery · 2022Article
- Analysis of lymph node spread and its prognostic significance in ampullary adenocarcinoma: A retrospective study.Frontiers in surgery · 2022Article
- Preoperative 2-[European radiology · 2021Article
- Investigation of the Indications for Endoscopic Papillectomy and Transduodenal Ampullectomy for Ampullary Tumors.Journal of clinical medicine · 2021Article
- Ampullary Carcinoma: An Overview of a Rare Entity and Discussion of Current and Future Therapeutic Challenges.Current oncology (Toronto, Ont.) · 2021Review
- Challenges in the management of adenocarcinoma of ampulla of Vater in pregnancy: A case report and review of literature.International journal of surgery case reports · 2019Article
- MicroRNA modulated networks of adaptive and innate immune response in pancreatic ductal adenocarcinoma.PloS one · 2019Article
- Ampulla of Vater carcinoma: Molecular landscape and clinical implications.World journal of gastrointestinal oncology · 2018Review
- Brain metastasis and herniation in a patient with ampullary adenocarcinoma presenting with jaundice and memory loss: case report.Journal of gastrointestinal oncology · 2018Article
- MicroRNA co-expression networks exhibit increased complexity in pancreatic ductal compared to Vater's papilla adenocarcinoma.Oncotarget · 2017Article
- Transduodenal ampullectomy provides a less invasive technique to cure early ampullary cancer.BMC surgery · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmpullary adenocarcinoma is considered to have a better prognosis than either pancreatic or bile duct adenocarcinoma. Pancreaticoduodenectomy is associated with significant mortality and morbidity. Some recent publications have advocated the use of endoscopic papillectomy for the treatment of early ampullary adenocarcinoma. This article reviews investigations and surgical treatment options of ampullary tumours.
methodsA systematic review of English-language articles was carried out using an electronic search of the Ovid MEDLINE (from 1996 onwards), PubMed and Cochrane Database of Systematic Reviews databases to identify studies related to the investigation and management of ampullary tumours.
resultsDistinguishing between ampullary adenoma and adenocarcinoma is challenging given the inaccuracy of endoscopic biopsy, for which high false negative rates of 25-50% have been reported. Endoscopic ultrasound is the most accurate method for local staging of ampullary lesions, but distinguishing between T1 and T2 adenocarcinomas is difficult. Lymph node metastasis occurs early in the disease process; it is lowest for T1 tumours, but the risk is still high at 8-45%. Case reports of successful endoscopic resection and transduodenal ampullectomy of T1 adenocarcinomas have been published, but their duration of follow-up is limited.
conclusionsOptimal staging should be used to distinguish between ampullary adenoma and adenocarcinoma. Pancreaticoduodenectomy remains the treatment of choice for all ampullary adenocarcinomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.