ArticlePloS one2013
Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- miRNA-27a is essential for bone remodeling by modulating p62-mediated osteoclast signaling.eLife · 2023Article
- BMPR1A maintains skeletal stem cell properties in craniofacial development and craniosynostosis.Science translational medicine · 2021Article
- The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis.BMB reports · 2018Article
- Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling Pathways During Skeletal Development.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development.Scientific reports · 2016Article
- Stem cells of the suture mesenchyme in craniofacial bone development, repair and regeneration.Nature communications · 2016Article
- Wls promotes the proliferation of breast cancer cells via Wnt signaling.Medical oncology (Northwood, London, England) · 2015Article
- Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration.PLoS genetics · 2014Article
- Focal chromosomal copy number aberrations identify CMTM8 and GPR177 as new candidate driver genes in osteosarcoma.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Aberrant regulation of the Wnt pathway, essential for various developmental processes, is tightly linked to human breast cancers. By hijacking this evolutionary conserved signaling pathway, cancer cells acquire sustaining proliferation ability, leading to modification of physiologic properties necessary for tumor initiation and progression. An enormous wealth of knowledge on the importance of Wnt signaling in breast development and cancer has been obtained, but the cell types responsible for production of this proliferative signal operating within normal and malignant tissues remains poorly understood. Here we report that Wnt production mediated by Gpr177 is essential for mammary morphogenesis. The loss of Gpr177 interferes with mammary stem cells, leading to deficiencies in cell proliferation and differentiation. Genetic analysis further demonstrates an indispensable role of Gpr177 in Wnt-induced tumorigenesis. The Gpr177-deficiency mice are resistant to malignant transformation. This study not only demonstrates the necessity of Wnt in mammary organogenesis but also provides a proof-of-principle for targeting of Gpr177 as a potential new treatment for human diseases with aberrant Wnt stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.