ArticlePloS one2013
An exploration of the serotonin system in antisocial boys with high levels of callous-unemotional traits.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- The genetic underpinnings of callous-unemotional traits: A systematic research review.Neuroscience and biobehavioral reviews · 2019Pooled it
- Maternal Mushroom Consumption During Pregnancy Is Associated With Decreased Risk of Peer Problems and Decreased Risk of Low Prosocial Behavior in 5-Year-Olds.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Article
- Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular Diseases.International journal of molecular sciences · 2023Review
- Psychopathic tendency in violent offenders is associated with reduced aversive Pavlovian inhibition of behavior and associated striatal BOLD signal.Frontiers in behavioral neuroscience · 2022Article
- SLC25A24 gene methylation and gray matter volume in females with and without conduct disorder: an exploratory epigenetic neuroimaging study.Translational psychiatry · 2021Article
- Association between autism spectrum disorder and polymorphisms in genes encoding serotine and dopamine receptors.Metabolic brain disease · 2021Article
- Population genetic variation ofJournal of genetics · 2021Article
- The role of serotonin 1B in the representation of outcomes.Scientific reports · 2019Article
- CAPE for measuring callous-unemotional traits in disadvantaged families: a cross-sectional validation study.F1000Research · 2019Article
- Born this way? A review of neurobiological and environmental evidence for the etiology of psychopathy.Personality neuroscience · 2019Review
- Serotonergic gene polymorphisms (5-HTTLPR, 5HTR1A, 5HTR2A), and population differences in aggression: traditional (Hadza and Datoga) and industrial (Russians) populations compared.Journal of physiological anthropology · 2018Article
- Callous-Unemotional Traits Moderate the Relation Between Prenatal Testosterone (2D:4D) and Externalising Behaviours in Children.Child psychiatry and human development · 2017Article
- Serotonin 1B Receptor Gene (HTR1B) Methylation as a Risk Factor for Callous-Unemotional Traits in Antisocial Boys.PloS one · 2015Article
- Callous-unemotional traits and the treatment of conduct problems in childhood and adolescence: a comprehensive review.Clinical child and family psychology review · 2014Review
- The neurobiology of psychopathic traits in youths.Nature reviews. Neuroscience · 2013Review
- Gene variants associated with antisocial behaviour: a latent variable approach.Journal of child psychology and psychiatry, and allied disciplines · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe serotonin system is thought to play a role in the aetiology of antisocial and aggressive behaviour in both adults and children however previous findings have been inconsistent. Recently, research has suggested that the function of the serotonin system may be specifically altered in a sub-set of antisocial populations - those with psychopathic (callous-unemotional) personality traits. We explored the relationships between callous-unemotional traits and functional polymorphisms of selected serotonin-system genes, and tested the association between callous-unemotional traits and serum serotonin levels independently of antisocial and aggressive behaviour.
methodParticipants were boys with antisocial behaviour problems aged 3-16 years referred to University of New South Wales Child Behaviour Research Clinics. Participants volunteered either a blood or saliva sample from which levels of serum serotonin (N = 66) and/or serotonin-system single nucleotide polymorphisms (N = 157) were assayed.
resultsFunctional single nucleotide polymorphisms from the serotonin 1b receptor gene (HTR1B) and 2a receptor gene (HTR2A) were found to be associated with callous-unemotional traits. Serum serotonin level was a significant predictor of callous-unemotional traits; levels were significantly lower in boys with high callous-unemotional traits than in boys with low callous-unemotional traits.
conclusionResults provide support to the emerging literature that argues for a genetically-driven system-wide alteration in serotonin function in the aetiology of callous-unemotional traits. The findings should be interpreted as preliminary and future research that aims to replicate and further investigate these results is required.
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