ArticlePloS one2013
Genomic insights into the glutathione S-transferase gene family of two rice planthoppers, Nilaparvata lugens (Stål) and Sogatella furcifera (Horváth) (Hemiptera: Delphacidae).
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 88 citations in OpenAlex.
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- RNAi-based functional analysis of a theta-class glutathione S-transferase implicated in deltamethrin detoxification inFrontiers in physiology · 2025Article
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- Antennae-enriched expression of candidate odorant degrading enzyme genes in the turnip aphid,Frontiers in physiology · 2023Article
- Comparative analysis of detoxification-related gene superfamilies across five hemipteran species.BMC genomics · 2022Article
- Glutathione S-Transferase May Contribute to the Detoxification of (S)-(-)-Palasonin inInsects · 2022Article
- Whole genome sequencing of spotted stem borer, Chilo partellus, reveals multiple genes encoding enzymes for detoxification of insecticides.Functional & integrative genomics · 2022Article
- A chromosome-level genome assembly of the orange wheat blossom midge, Sitodiplosis mosellana Géhin (Diptera: Cecidomyiidae) provides insights into the evolution of a detoxification system.G3 (Bethesda, Md.) · 2022Article
- Identification and characterization of candidate detoxification genes inFrontiers in physiology · 2022Article
- The Key Glutathione S-Transferase Family Genes Involved in the Detoxification of Rice Gramine in Brown PlanthopperInsects · 2021Article
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- RNA-Sequencing Reveals Differentially Expressed Rice Genes Functionally Associated with Defense against BPH and WBPH in RILs Derived from a Cross between RP2068 and TN1.Rice (New York, N.Y.) · 2021Article
- Effects of Glutathione on Growth, Intestinal Antioxidant Capacity, Histology, Gene Expression, and Microbiota of Juvenile TriploidFrontiers in physiology · 2021Article
- Molecular Evolution of the Glutathione S-Transferase Family in the Bemisia tabaci Species Complex.Genome biology and evolution · 2020Article
- Molecular Characterization of Vitellogenin and Its Receptor inFrontiers in physiology · 2019Article
- Plant-Mediated Silencing of the WhiteflyFrontiers in physiology · 2019Article
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlutathione S-transferase (GST) genes control crucial traits for the metabolism of various toxins encountered by insects in host plants and the wider environment, including insecticides. The planthoppers Nilaparvata lugens and Sogatella furcifera are serious specialist pests of rice throughout eastern Asia. Their capacity to rapidly adapt to resistant rice varieties and to develop resistance to various insecticides has led to severe outbreaks over the last decade. METHODOLOGY/PRINCIPAL
findingsUsing the genome sequence of N. lugens, we identified for the first time the complete GST gene family of a delphacid insect whilst nine GST gene orthologs were identified from the closely related species S. furcifera. Nilaparvata lugens has 11 GST genes belonging to six cytosolic subclasses and a microsomal class, many fewer than seen in other insects with known genomes. Sigma is the largest GST subclass, and the intron-exon pattern deviates significantly from that of other species. Higher GST gene expression in the N. lugens adult migratory form reflects the higher risk of this life stage in encountering the toxins of non-host plants. After exposure to a sub-lethal dose of four insecticides, chlorpyrifos, imidacloprid, buprofezin or beta-cypermethrin, more GST genes were upregulated in S. furcifera than in N. lugens. RNA interference targeting two N. lugens GST genes, NlGSTe1 and NlGSTm2, significantly increased the sensitivity of fourth instar nymphs to chlorpyrifos but not to beta-cypermethrin. CONCLUSIONS/SIGNIFICANCE: This study provides the first elucidation of the nature of the GST gene family in a delphacid species, offering new insights into the evolution of metabolic enzyme genes in insects. Further, the use of RNA interference to identify the GST genes induced by insecticides illustrates likely mechanisms for the tolerance of these insects.
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