Trial reportPloS one2013
Is transcranial alternating current stimulation effective in modulating brain oscillations?
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05085210 (Visual Restoration of Losses Caused by Cortical Damage), which is not on this map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Visual Restoration of Losses Caused by Cortical Damage: a New Protocol to Promote Fast Recovery
Who cites it
51 citing papers in PubMed, 105 citations in OpenAlex.
- Efficacy of tRNS and 140 Hz tACS on motor cortex excitability seemingly dependent on sensitivity to sham stimulation.Experimental brain research · 2019Trial
- Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings.Nature communications · 2017Trial
- Investigating the role of beta and gamma tACS in visual processing and conscious perception.Neuroscience of consciousness · 2026Article
- Neural changes to transcranial alternating current stimulation in the gamma range over the left frontoparietal network: A preliminary eLORETA EEG study.AIMS neuroscience · 2026Article
- What can neurofeedback and transcranial alternating current stimulation reveal about cross-frequency coupling?Frontiers in neuroscience · 2025Article
- Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG study.AIMS neuroscience · 2024Article
- Target engagement of the subgenual anterior cingulate cortex with transcranial temporal interference stimulation in major depressive disorder: a protocol for a randomized sham-controlled trial.Frontiers in neuroscience · 2024Article
- The effect of montages of transcranial alternating current stimulation on occipital responses-a sham-controlled pilot study.Frontiers in psychiatry · 2023Article
- 10 Minutes Frontal 40 Hz tACS-Effects on Working Memory Tested by Luck-Vogel Task.Behavioral sciences (Basel, Switzerland) · 2022Article
- Non-invasive brain stimulation and neuroenhancement.Clinical neurophysiology practice · 2022Review
- Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform.Nature communications · 2021Article
- Tinnitus and Brain Stimulation.Current topics in behavioral neurosciences · 2021Article
- Article
- A Comparison of Closed Loop vs. Fixed Frequency tACS on Modulating Brain Oscillations and Visual Detection.Frontiers in human neuroscience · 2021Article
- Parametric study of transcranial alternating current stimulation for brain alpha power modulation.Brain communications · 2021Article
- The Modulation of Cognitive Performance with Transcranial Alternating Current Stimulation: A Systematic Review of Frequency-Specific Effects.Brain sciences · 2020Review
- Removal of the Sinusoidal Transorbital Alternating Current Stimulation Artifact From Simultaneous EEG Recordings: Effects of Simple Moving Average Parameters.Frontiers in neuroscience · 2020Article
- Article
- Human Sensation of Transcranial Electric Stimulation.Scientific reports · 2019Article
- 10 Hz tACS Over Somatosensory Cortex Does Not Modulate Supra-Threshold Tactile Temporal Discrimination in Humans.Frontiers in neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial alternating current stimulation (tACS) is a promising tool for modulating brain oscillations, as well as a possible therapeutic intervention. However, the lack of conclusive evidence on whether tACS is able to effectively affect cortical activity continues to limit its application. The present study aims to address this issue by exploiting the well-known inhibitory alpha rhythm in the posterior parietal cortex during visual perception and attention orientation. Four groups of healthy volunteers were tested with a Gabor patch detection and discrimination task. All participants were tested at the baseline and selective frequencies of tACS, including Sham, 6 Hz, 10 Hz, and 25 Hz. Stimulation at 6 Hz and 10 Hz over the occipito-parietal area impaired performance in the detection task compared to the baseline. The lack of a retinotopically organised effect and marginal frequency-specificity modulation in the detection task force us to be cautious about the effectiveness of tACS in modulating brain oscillations. Therefore, the present study does not provide significant evidence for tACS reliably inducing direct modulations of brain oscillations that can influence performance in a visual task.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.