ArticlePloS one2013
DNA methylation analysis of allotetraploid hybrids of red crucian carp (Carassius auratus red var.) and common carp (Cyprinus carpio L.).
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Establishment and Biological Characteristics Analysis of a Hybrid Culter Lineage fromAnimals : an open access journal from MDPI · 2025Article
- Stage-specific transcriptomic and DNA methylation responses to triploidy in European sea bass embryos and larvae.BMC genomics · 2025Article
- The alternative transcription and expression characterization ofFrontiers in genetics · 2023Article
- Genome-Wide Differential DNA Methylomes Provide Insights into the Infertility of Triploid Oysters.Marine biotechnology (New York, N.Y.) · 2022Article
- Studying phenotypic variation and DNA methylation across development, ecology and evolution in the clonal marbled crayfish: a paradigm for investigating epigenotype-phenotype relationships in macro-invertebrates.Die Naturwissenschaften · 2022Review
- Epigenetic variation in animal populations: Sources, extent, phenotypic implications, and ecological and evolutionary relevance.Journal of biosciences · 2021Review
- Using asexual vertebrates to study genome evolution and animal physiology: Banded (Evolutionary applications · 2020Article
- Genetic and Epigenetic Changes Are Rapid Responses of the Genome to the Newly Synthesized AutotetraploidFrontiers in genetics · 2020Article
- Whole Genome Incorporation and Epigenetic Stability in a Newly Synthetic Allopolyploid of Gynogenetic Gibel Carp.Genome biology and evolution · 2018Article
- Memory Function in Feeding Habit Transformation of Mandarin Fish (International journal of molecular sciences · 2018Article
- Differential DNA methylation and gene expression in reciprocal hybrids between Solanum lycopersicum and S. pimpinellifolium.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Facilitation of environmental adaptation and evolution by epigenetic phenotype variation: insights from clonal, invasive, polyploid, and domesticated animals.Environmental epigenetics · 2017Review
- MicroRNA profiles reveal female allotetraploid hybrid fertility.BMC genetics · 2015Article
- Rapid genomic DNA changes in allotetraploid fish hybrids.Heredity · 2015Article
- Article
- Epigenetic control of mobile DNA as an interface between experience and genome change.Frontiers in genetics · 2014Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hybridization and polyploidization may lead to divergence in adaptation and boost speciation in angiosperms and some lower animals. Epigenetic change plays a significant role in the formation and adaptation of polyploidy. Studies of the effects of methylation on genomic recombination and gene expression in allopolyploid plants have achieved good progress. However, relevant advances in polyploid animals have been relatively slower. In the present study, we used the bisexual, fertile, genetically stable allotetraploid generated by hybridization of Carassius auratus red var. and Cyprinus carpio L. to investigate cytosine methylation level using methylation-sensitive amplification polymorphism (MSAP) analysis. We observed 38.31% of the methylation changes in the allotetraploid compared with the parents at 355 randomly selected CCGG sites. In terms of methylation status, these results indicate that the level of methylation modification in the allotetraploid may have increased relative to that in the parents. We also found that the major methylation changes were hypermethylation on some genomic fragments and genes related to metabolism or cell cycle regulation. These results provide circumstantial evidence that DNA methylation might be related to the gene expression and phenotype variation in allotetraploid hybrids. Our study partly fulfils the need for epigenetic research in polyploid animals, and provides evidence for the epigenetic regulation of allopolyploids.
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