ArticlePloS one2013
Does the number of oocytes retrieved influence pregnancy after fresh embryo transfer?
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- The Association Between Mature Oocyte Proportion and IVF Success: A Retrospective Analysis of 2,565 ICSI Cycles.Journal of reproduction & infertility · 2025Article
- Stimulation Duration in Patients with Early Oocyte Maturation Triggering Criteria Does Not Impact IVF-ICSI Outcomes.Journal of clinical medicine · 2022Article
- Risk factors for twin pregnancy in women undergoing double cleavage embryo transfer.BMC pregnancy and childbirth · 2022Article
- Outcomes After a Single Ovarian Stimulation Cycle in Women of Advanced Reproductive Age: A Retrospective Analysis.Frontiers in endocrinology · 2022Article
- Optimal Oocyte Number in Controlled Ovarian Stimulation with Gonadotropin-Releasing Hormone Agonist/Antagonist and Day 3 Fresh Embryo Transfer.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Evaluation of the relationship between serum estradiol levels on human chorionic gonadotropin administration day and intracytoplasmic sperm injection outcomes: A retrospective population-based study.International journal of reproductive biomedicine · 2021Article
- Antiphospholipid antibodies levels and potential effects on in-vitro fertilization in a large cohort of infertile Syrian women.Annals of medicine and surgery (2012) · 2021Article
- Optimal numbers of mature oocytes to produce at least one or multiple top-quality day-3 embryos in normal responders.Clinical and experimental reproductive medicine · 2020Article
- Human Recombinant FSH and Its Biosimilars: Clinical Efficacy, Safety, and Cost-Effectiveness in Controlled Ovarian Stimulation for In Vitro Fertilization.Pharmaceuticals (Basel, Switzerland) · 2020Review
- The impact of follicle-flushing during oocyte collection on embryo development of in-vitro fertilization.Reproductive biology and endocrinology : RB&E · 2019Article
- Electroacupuncture Enhances Number of Mature Oocytes and Fertility Rates forMedical acupuncture · 2019Article
- Smoking Decreases Endometrial Thickness in IVF/ICSI Patients.Geburtshilfe und Frauenheilkunde · 2018Article
- The novel POSEIDON stratification of 'Low prognosis patients in Assisted Reproductive Technology' and its proposed marker of successful outcome.F1000Research · 2016Article
- Does Unilateral Oocyte Retrieval due to Transvaginally Inaccessible Ovaries, Contrary to Common Beliefs, Affect IVF/ICSI Treatment Outcomes That Much?BioMed research international · 2016Article
- Is the presence of a non-cleaved embryo on day 3 associated with poorer quality of the remaining embryos in the cohort?Journal of assisted reproduction and genetics · 2015Article
- Association of number of retrieved oocytes with live birth rate and birth weight: an analysis of 231,815 cycles of in vitro fertilization.Fertility and sterility · 2015Article
- Quality of embryos transferred and progesterone levels are the most important predictors of live birth after fresh embryo transfer: a retrospective cohort study.Journal of assisted reproduction and genetics · 2014Article
- Cumulative Live Birth Rate per Oocyte Aspiration in Artificial Reproduction Technology: A Retrospective Observational Study of the Association between Maternal Age and the Number of Oocytes Retrieved in an Indian Population.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe nature of the association between the number of oocytes retrieved and in vitro fertilization (IVF) outcomes after fresh embryo transfer remains unclear because of conflicting results reported in the studies on this subject. In addition, the influence of the quality of the embryos transferred is usually neglected. The objective of this study is to assess the relationships of the number of oocytes retrieved, the number and quality of embryos transferred, and the prospects of pregnancy after fresh embryo transfer.
methodsThe data on 3131 infertile women undergoing their first IVF treatment cycle between January 2009 and December 2010 were collected retrospectively. Restricted cubic splines and stratified analyses were used to explore the relationships between the number of oocytes retrieved, the number and quality of embryos transferred, and the IVF outcomes.
resultsWhen stratified by the number and quality of transferred embryos, no significant differences in the chances for clinical pregnancy and live birth were found in three groups of oocytes yielded (≤6, 7-14, or ≥15). The relationship between the number of oocytes retrieved and pregnancy is nearly a reflection of the pattern of the relationship between the number of oocytes retrieved and the probability of having two good-quality embryos transferred. The patients with the "optimal" number of oocytes were not only younger but also had the highest probability of having two good-quality embryos replaced.
conclusionsSimilarly aged patients have similar pregnancy prospects after fresh embryo transfer when the same number and quality of embryos are replaced, irrespective of their number of oocytes. Selecting the desired number of good-quality embryos for transfer is the key to IVF success. Thus, aiming at retrieving an optimal number of oocytes to maximize IVF outcomes in a fresh cycle could place undue stress on the patients and may not be the best medical decision.
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