ArticlePloS one2013
VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Integrating genome and transcriptome-wide data to explore the expression dynamics ofFrontiers in plant science · 2025Article
- The Oxidative Stress in Epilepsy-Focus on Melatonin.International journal of molecular sciences · 2024Review
- Targeting catalase in cancer.Redox biology · 2024Review
- Age-related factors that affect B cell responses to vaccination in mice and humans.Immunological reviews · 2020Review
- Peroxisomal abnormalities and catalase deficiency in Hutchinson-Gilford Progeria Syndrome.Aging · 2020Article
- Peroxisome: Metabolic Functions and Biogenesis.Advances in experimental medicine and biology · 2020Review
- Microhomology-based CRISPR tagging tools for protein tracking, purification, and depletion.The Journal of biological chemistry · 2019Article
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- Peroxisomes sense and respond to environmental cues by regulating ROS and RNS signalling networks.Annals of botany · 2015Review
- Proteomics of muscle chronological ageing in post-menopausal women.BMC genomics · 2014Article
- Caenorhabditis elegans: A useful model for studying metabolic disorders in which oxidative stress is a contributing factor.Oxidative medicine and cellular longevity · 2014Review
- Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives.Frontiers in physiology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catalase is a key antioxidant enzyme that catalyzes the decomposition of hydrogen peroxide (H2O2) to water and oxygen, and it appears to shuttle between the cytoplasm and peroxisome via unknown mechanisms. Valosin-containing protein (VCP) belongs to the AAA class of ATPases and is involved in diverse cellular functions, e.g. cell cycle and protein degradation, etc. Here we show that VCP and PEX19, a protein essential for peroxisome biogenesis, interact with each other. Knockdown of either VCP or PEX19 resulted in a predominantly cytoplasmic redistribution of catalase, and loss of VCP ATPase activity also increased its cytoplasmic redistribution. Moreover, VCP knockdown decreased intracellular ROS levels in normal and H2O2-treated cells, and an oxidation-resistant VCP impaired the ROS-induced cytoplasmic redistribution of catalase. These observations reveal a novel feedback mechanism, in which VCP can sense H2O2 levels, and regulates them by controlling the localization of catalase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.