ArticlePloS one2013
Novel isoforms of the transport regulator klar.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Drosophila KASH-domain protein Klarsicht regulates microtubule stability and integrin receptor localization during collective cell migration.Developmental biology · 2015Article
- As the fat flies: The dynamic lipid droplets of Drosophila embryos.Biochimica et biophysica acta · 2015Review
- Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.G3 (Bethesda, Md.) · 2015Article
- Klar ensures thermal robustness of oskar localization by restraining RNP motility.The Journal of cell biology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Klar is a regulator of microtubule-motor dependent transport processes in Drosophila, including nuclear migration, vesicle motility, and lipid-droplet transport. The single klar locus gives rise to multiple isoforms that presumably have unique functions. Up to now, three Klar isoforms (α, β, γ) were known. Here we describe two novel isoforms, δ and ε, whose expression depends on a previously uncharacterized promoter. Klar δ and/or ε are widely expressed during development, including in the embryonic and larval nervous system as well as in ovaries. When we specifically ablate Klar δ and ε expression genetically, no gross organismal phenotypes are apparent. However, ectopic expression of these isoforms causes nuclear mispositioning in developing photoreceptors and in oocytes, demonstrating their biological activity. Our analysis identifies novel forms of the Klar protein and provides new tools for functionally dissecting the complex klar locus.
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Registered trials
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