ArticleThe Journal of biological chemistry2013
Specific activation of the G protein-coupled receptor BNGR-A21 by the neuropeptide corazonin from the silkworm, Bombyx mori, dually couples to the G(q) and G(s) signaling cascades.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 40 citations in OpenAlex.
- CRISPR/Cas9-Mediated Knockout of theInsects · 2025Article
- Review
- Corazonin Stimulates Ecdysteroid Synthesis during the Molting Process of the Swimming Crab,Biology · 2024Article
- Article
- Identification of neuropeptides and neuropeptide receptor genes in Phauda flammans (Walker).Scientific reports · 2022Article
- Maternal GABAergic and GnRH/corazonin pathway modulates egg diapause phenotype of the silkwormProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Enteroendocrine peptides regulate feeding behavior via controlling intestinal contraction of the silkworm Bombyx mori.PloS one · 2019Article
- BNGR-A25L and -A27 are two functional G protein-coupled receptors for CAPA periviscerokinin neuropeptides in the silkwormThe Journal of biological chemistry · 2017Article
- Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy.Journal of visualized experiments : JoVE · 2017Article
- Invertebrate Gonadotropin-Releasing Hormone-Related Peptides and Their Receptors: An Update.Frontiers in endocrinology · 2017Review
- A Role of Corazonin Receptor in Larval-Pupal Transition and Pupariation in the Oriental Fruit FlyFrontiers in physiology · 2017Article
- Identification and expression profiles of neuropeptides and their G protein-coupled receptors in the rice stem borer Chilo suppressalis.Scientific reports · 2016Article
- Identification and Characterization of the Corazonin Receptor and Possible Physiological Roles of the Corazonin-Signaling Pathway in Rhodnius prolixus.Frontiers in neuroscience · 2016Article
- Article
- Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corazonin, an undecapeptide neurohormone sharing a highly conserved amino acid sequence across Insecta, plays different physiological roles in the regulation of heart contraction rates, silk spinning rates, the induction of dark color and morphometric phase changes, and ecdysis. Corazonin receptors have been identified in Drosophila melanogaster, Manduca sexta, and Musca domestica. However, detailed information on the signaling and major physiological functions of corazonin and its receptor is largely unknown. In the current study, using both the mammalian cell line HEK293 and insect cell lines BmN and Sf21, we paired the Bombyx corazonin neuropeptide as a specific endogenous ligand for the Bombyx neuropeptide G protein-coupled receptor A21 (BNGR-A21), and we therefore designated this receptor as BmCrzR. Further characterization indicated that synthetic BmCrz demonstrated a high affinity for and activated BmCrzR, resulting in intracellular cAMP accumulation, Ca(2+) mobilization, and ERK1/2 phosphorylation via the Gq- and Gs-coupled signaling pathways. The direct interaction of BmCrzR with BmCrz was confirmed by a rhodamine-labeled BmCrz peptide. Moreover, experiments with double-stranded RNA and synthetic peptide injection suggested a possible role of BmCrz/BmCrzR in the regulation of larval growth and spinning rate. Our present results provide the first in-depth information on BmCrzR-mediated signaling for further elucidation of the BmCrz/BmCrzR system in the regulation of fundamental physiological processes.
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