ReviewCold Spring Harbor perspectives in biology2013
Evolution of the animal apoptosis network.
Review in Cold Spring Harbor perspectives in biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Can Environmental Enrichment Mitigate Cell Apoptosis in the Central Nervous System Under Adverse Health Conditions? A Systematic Review.Clinical and translational science · 2026Pooled it
- Oxygen Deprivation Implicated in Rapid Coral Mortality Under Acute Heating Events.Global change biology · 2026Article
- Apoptosis as an evolutionary battleground: pathogen pressure and the shaping of programmed cell death pathways.Frontiers in cell and developmental biology · 2026Review
- Deciphering the topological landscape of glioma using a network theory framework.Scientific reports · 2024Article
- Evolution of Apoptotic Signaling Pathways Within Lophotrochozoans.Genome biology and evolution · 2024Article
- Article
- Intrinsic apoptosis is evolutionarily divergent among metazoans.Evolution letters · 2024Article
- Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate Ciona.Scientific reports · 2024Article
- The role of PB1-F2 in adaptation of high pathogenicity avian influenza virus H7N7 in chickens.Veterinary research · 2024Article
- Withania somnifera inhibits photorefractoriness which triggers neuronal apoptosis in both pre-optic and paraventricular hypothalamic area of Coturnix coturnix japonica: involvement of oxidative stress induced p53 dependent Caspase-3 mediated low immunoreactivity of estrogen receptor alpha.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family.International journal of molecular sciences · 2022Article
- The expanded inhibitor of apoptosis gene family in oysters possesses novel domain architectures and may play diverse roles in apoptosis following immune challenge.BMC genomics · 2022Article
- Evolutionary Profile for (Host and Viral) MLKL Indicates Its Activities as a Battlefront for Extensive Counteradaptation.Molecular biology and evolution · 2021Article
- Phylogenetic analysis of the caspase family in bivalves: implications for programmed cell death, immune response and development.BMC genomics · 2021Article
- Analysis of Apoptosis-Related Genes Reveals that Apoptosis Functions in Conidiation and Pathogenesis ofmSphere · 2021Article
- Regulation of Cell Death by Mitochondrial Transport Systems of Calcium and Bcl-2 Proteins.Membranes · 2020Review
- Acetylcholinesterase promotes apoptosis in insect neurons.Apoptosis : an international journal on programmed cell death · 2020Article
- The structural basis of Bcl-2 mediated cell death regulation in hydra.The Biochemical journal · 2020Article
- Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis.Science advances · 2020Article
- Novel Apoptotic Mediators Identified by Conservation of Vertebrate Caspase Targets.Biomolecules · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of available eukaryotic genomes has expanded to the point where we can evaluate the complete evolutionary history of many cellular processes. Such analyses for the apoptosis regulatory networks suggest that this network already existed in the ancestor of the entire animal kingdom (Metazoa) in a form more complex than in some popular animal model organisms. This supports the growing realization that regulatory networks do not necessarily evolve from simple to complex and that the relative simplicity of these networks in nematodes and insects does not represent an ancestral state, but is the result of secondary simplifications. Network evolution is not a process of monotonous increase in complexity, but a dynamic process that includes lineage-specific gene losses and expansions, protein domain reshuffling, and emergence/reemergence of similar protein architectures by parallel evolution. Studying the evolution of such networks is a challenging yet interesting subject for research and investigation, and such studies on the apoptosis networks provide us with interesting hints of how these networks, critical in so many human diseases, have developed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.