ArticleJournal of bacteriology2013
Positive feedback regulation of stgR expression for secondary metabolism in Streptomyces coelicolor.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Actinobacteria TFDB: An integrated view of transcription factors in Actinobacteria.Engineering microbiology · 2026Article
- A precisely regulated Streptomyces expression system pTZYp facilitated by the strong promoter stnY and cmt operon.Biotechnology letters · 2025Article
- The DNA cytosine methylome revealed two methylation motifs in the upstream regions of genes related to morphological and physiological differentiation in Streptomyces coelicolor A(3)2 M145.Scientific reports · 2023Article
- Curation, inference, and assessment of a globally reconstructed gene regulatory network for Streptomyces coelicolor.Scientific reports · 2022Article
- Regulatory and biosynthetic effects of the bkd gene clusters on the production of daptomycin and its analogs A21978CJournal of industrial microbiology & biotechnology · 2018Article
- A GntR Family Transcription Factor inFrontiers in microbiology · 2018Article
- Regulatory genes and their roles for improvement of antibiotic biosynthesis in Streptomyces.3 Biotech · 2017Review
- Discovery ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Biosynthesis of the acetyl-CoA carboxylase-inhibiting antibiotic, andrimid in Serratia is regulated by Hfq and the LysR-type transcriptional regulator, AdmX.Environmental microbiology · 2016Article
- DepR1, a TetR Family Transcriptional Regulator, Positively Regulates Daptomycin Production in an Industrial Producer, Streptomyces roseosporus SW0702.Applied and environmental microbiology · 2016Article
- The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation.Applied and environmental microbiology · 2015Article
- Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination.Journal of the American Chemical Society · 2015Article
- Transcriptional regulation of the daptomycin gene cluster in Streptomyces roseosporus by an autoregulator, AtrA.The Journal of biological chemistry · 2015Article
- Dual positive feedback regulation of protein degradation of an extra-cytoplasmic function σ factor for cell differentiation in Streptomyces coelicolor.The Journal of biological chemistry · 2013Article
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7 authors.
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Abstract
LysR-type transcriptional regulators (LTTRs) compose a large family and are responsible for various physiological functions in bacteria, while little is understood about their regulatory mechanism on secondary metabolism in Streptomyces. Here we reported that StgR, a typical LTTR in Streptomyces coelicolor, was a negative regulator of undecylprodigiosin (Red) and γ-actinorhodin (Act) production in the early developmental phase of secondary metabolism by suppressing the expression of two pathway-specific regulator genes, redD and actII-orf4, respectively. Meanwhile, stgR expression was downregulated during secondary metabolism to remove its repressive effects on antibiotic production. Moreover, stgR expression was positively autoregulated by direct binding of StgR to its own promoter (stgRp), and the binding site adjacent to translation start codon was determined by a DNase I footprinting assay. Furthermore, the StgR-stgRp interaction could be destroyed by the antibiotic γ-actinorhodin produced from S. coelicolor. Thus, our results suggested a positive feedback regulatory mechanism of stgR expression and antibiotic production for the rapid and irreversible development of secondary metabolism in Streptomyces.
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