ArticleGenetics2013
The SWI/SNF chromatin remodeling complex selectively affects multiple aspects of serotonergic neuron differentiation.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Cell type-specific functions of the PBAF chromatin-remodeling complex in neuronal diversification.Nature communications · 2025Article
- SWI/SNF complex, promising target in melanoma therapy: Snapshot view.Frontiers in medicine · 2023Review
- The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion in vivo.PLoS genetics · 2022Article
- New alleles of the SWI/SNF chromatin remodeling complex genemicroPublication biology · 2022Article
- The regulatory landscape of neurite development inFrontiers in molecular neuroscience · 2022Review
- Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner.Frontiers in molecular neuroscience · 2021Article
- Using Zebrafish to Model Autism Spectrum Disorder: A Comparison of ASD Risk Genes Between Zebrafish and Their Mammalian Counterparts.Frontiers in molecular neuroscience · 2020Review
- The BAF complex in development and disease.Epigenetics & chromatin · 2019Review
- The role of ARID1B, a BAF chromatin remodeling complex subunit, in neural development and behavior.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
- Regulation of chromatin states and gene expression during HSN neuronal maturation is mediated by EOR-1/PLZF, MAU-2/cohesin loader, and SWI/SNF complex.Scientific reports · 2018Article
- A transcription factor collective defines the HSN serotonergic neuron regulatory landscape.eLife · 2018Article
- The C. elegans Spalt-like protein SEM-4 functions through the SoxC transcription factor SEM-2 to promote a proliferative blast cell fate in the postembryonic mesoderm.Developmental biology · 2017Article
- Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states.Nature genetics · 2017Article
- Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and Disorders.Frontiers in molecular neuroscience · 2017Review
- Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops.Neuron · 2016Review
- Article
- SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Role of nucleosome remodeling in neurodevelopmental and intellectual disability disorders.Frontiers in behavioral neuroscience · 2015Review
- The role of BAF (mSWI/SNF) complexes in mammalian neural development.American journal of medical genetics. Part C, Seminars in medical genetics · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Regulatory programs that control the specification of serotonergic neurons have been investigated by genetic mutant screens in the nematode Caenorhabditis elegans. Loss of a previously uncloned gene, ham-3, affects migration and serotonin antibody staining of the hermaphrodite-specific neuron (HSN) pair. We characterize these defects here in more detail, showing that the defects in serotonin antibody staining are paralleled by a loss of the transcription of all genes involved in serotonin synthesis and transport. This loss is specific to the HSN class as other serotonergic neurons appear to differentiate normally in ham-3 null mutants. Besides failing to migrate appropriately, the HSNs also display axon pathfinding defects in ham-3 mutants. However, the HSNs are still generated and express a subset of their terminal differentiation features in ham-3 null mutants, demonstrating that ham-3 is a specific regulator of select features of the HSNs. We show that ham-3 codes for the C. elegans ortholog of human BAF60, Drosophila Bap60, and yeast Swp73/Rsc6, which are subunits of the yeast SWI/SNF and vertebrate BAF chromatin remodeling complex. We show that the effect of ham-3 on serotonergic fate can be explained by ham-3 regulating the expression of the Spalt/SALL-type Zn finger transcription factor sem-4, a previously identified regulator of serotonin expression in HSNs and of the ham-2 Zn transcription factor, a previously identified regulator of HSN migration and axon outgrowth. Our findings provide the first evidence for the involvement of the BAF complex in the acquisition of terminal neuronal identity and constitute genetic proof by germline knockout that a BAF complex component can have cell-type-specific roles during development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.