ReviewEuropean respiratory review : an official journal of the European Respiratory Society2013
Thymic epithelial tumours: from basic principles to individualised treatment strategies.
Review in European respiratory review : an official journal of the European Respiratory Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- PRRC2A-mediated mCell death & disease · 2026Article
- Neoadjuvant chemotherapy enabling resection of stage IVA thymoma with myasthenia gravis and systemic lupus erythematosus: a case report.Frontiers in oncology · 2026Article
- Narrative review: locally advanced thymoma-do we really need induction therapy before extended resection?Mediastinum (Hong Kong, China) · 2026Review
- Applying expertise: Extrapleural pneumonectomy and extended pleurectomy decortication in the management of Masaoka-Koga stage IV thymoma.JTCVS open · 2025Article
- Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus.Developmental cell · 2023Article
- Differentiating thymic epithelial tumors from mediastinal lymphomas: preoperative nomograms based on PET/CT radiomic features to minimize unnecessary anterior mediastinal surgery.Journal of cancer research and clinical oncology · 2023Article
- Promotor methylation status of MAPK4 is a novel epigenetic biomarker for prognosis of recurrence in patients with thymic epithelial tumors.Thoracic cancer · 2022Article
- SEOM-GECP-GETTHI Clinical Guidelines for the treatment of patients with thymic epithelial tumours (2021).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Article
- The role of surgery in advanced thymic tumors: A retrospective cohort study.Frontiers in oncology · 2022Article
- Current Roles of PET/CT in Thymic Epithelial Tumours: Which Evidences and Which Prospects? A Pictorial Review.Cancers · 2021Review
- Systemic treatments for thymic tumors: a narrative review.Mediastinum (Hong Kong, China) · 2021Review
- Article
- Surgery in Masaoka stage IV thymic carcinoma: a propensity-matched study based on the SEER database.Journal of thoracic disease · 2020Article
- Managing Metastatic Thymoma With Metabolic and Medical Therapy: A Case Report.Frontiers in oncology · 2020Article
- Complete excision of acute necrotic regression of thymoma mimicking an infected mediastinal cyst with mediastinitis using video-assisted thoracoscopic technique.Journal of thoracic disease · 2018Article
- Expression of cell cycle and apoptosis regulators in thymus and thymic epithelial tumors.Clinical and experimental medicine · 2016Review
- New findings on thymic epithelial tumors: Something is changing.World journal of clinical oncology · 2015Article
- The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2015Review
- Multimodality treatment for advanced thymic carcinoma: outcomes of induction therapy followed by surgical resection in 16 cases at a single institution.General thoracic and cardiovascular surgery · 2015Article
- Crucial role of treatment with palliative intent for a patient with advanced thymic carcinoma.Oncology letters · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thymic epithelial tumours represent a wide range of anatomical, clinical, histological and molecular malignant entities that may be aggressive and difficult to treat. The histopathological classification distinguishes thymomas from thymic carcinomas. Thymomas may be associated with autoimmune disorders. The management of thymic epithelial tumours is a paradigm of co-operation between clinicians, surgeons and pathologists, from establishing the diagnosis to organising the multimodal therapeutic strategy. Surgery is the mainstay of the curative-intent treatment, as complete resection represents the most significantly favourable prognostic factor on overall survival. In case of invasion of intra-thoracic structures and/or dissemination to the pleura and the pericardium, precluding complete resection to be achieved, primary chemotherapy has been used to reduce the tumour burden, possibly allowing subsequent surgery and/or radiotherapy. Novel strategies are needed, especially for refractory, recurrent tumours and thymic carcinomas, which carry a poor prognosis. Personalised approaches are currently being developed, as potentially "druggable" molecular targets are emerging from recent integrated genomic analyses. Along with the large variety of questions relative to the treatment strategy, thymic epithelial tumours represent a model of therapeutic implementation and achievement in orphan thoracic oncology, showing how the advent of new results induces new questions, as well as diversifies further clinical research directions and international collaborative initiatives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.