ReviewAdvances in experimental medicine and biology2013
Targeting the skin for microneedle delivery of influenza vaccine.
Review in Advances in experimental medicine and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Fabrication of microneedle patches with lyophilized influenza vaccine suspended in organic solvent.Drug delivery and translational research · 2021Article
- Self-healing encapsulation and controlled release of vaccine antigens from PLGA microparticles delivered by microneedle patches.Bioengineering & translational medicine · 2019Article
- Stable incorporation of GM-CSF into dissolvable microneedle patch improves skin vaccination against influenza.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Skin immunization by microneedle patch overcomes statin-induced suppression of immune responses to influenza vaccine.Scientific reports · 2017Article
- Tolerability, usability and acceptability of dissolving microneedle patch administration in human subjects.Biomaterials · 2017Article
- Self-Assembly DNA Polyplex Vaccine inside Dissolving Microneedles for High-Potency Intradermal Vaccination.Theranostics · 2017Article
- Fluzone® intra-dermal (Intanza®/Istivac® Intra-dermal): An updated overview.Human vaccines & immunotherapeutics · 2016Review
- Enhanced Stability of Inactivated Influenza Vaccine Encapsulated in Dissolving Microneedle Patches.Pharmaceutical research · 2016Article
- Enhanced immune responses by skin vaccination with influenza subunit vaccine in young hosts.Vaccine · 2015Article
- Inactivated polio vaccination using a microneedle patch is immunogenic in the rhesus macaque.Vaccine · 2015Article
- Improved immunogenicity of individual influenza vaccine components delivered with a novel dissolving microneedle patch stable at room temperature.Drug delivery and translational research · 2015Article
- Modulation of influenza vaccine immune responses using an epidermal growth factor receptor kinase inhibitor.Scientific reports · 2015Article
- Development of a thermostable microneedle patch for influenza vaccination.Journal of pharmaceutical sciences · 2015Article
- Effect of vaccine administration modality on immunogenicity and efficacy.Expert review of vaccines · 2015Review
- Colocalization of cell death with antigen deposition in skin enhances vaccine immunogenicity.The Journal of investigative dermatology · 2014Article
- A protective role of murine langerin⁺ cells in immune responses to cutaneous vaccination with microneedle patches.Scientific reports · 2014Article
- Hydrogel-forming microneedles prepared from "super swelling" polymers combined with lyophilised wafers for transdermal drug delivery.PloS one · 2014Article
- Influenza vaccines: unmet needs and recent developments.Infection & chemotherapy · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Influenza infection represents a major socioeconomic burden worldwide. Skin represents a new target that has gained much attention in recent years for delivery of influenza vaccine as an alternative to the conventional intramuscular route of immunization. In this review we describe different microneedle vaccination approaches used in vivo, including metal and dissolving microneedle patches that have demonstrated promising results. Additionally we analyze the immunological basis for microneedle skin immunization and targeting of the skin's dense population of antigen presenting cells, their role, characterization, and function. Additionally we analyze the importance of inflammatory signaling in the skin after microneedle delivery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.