ReviewCurrent neurology and neuroscience reports2013
Chronopharmacology of anti-convulsive therapy.
Review in Current neurology and neuroscience reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Dual mechanism of anti-seizure medications in controlling seizure activity.Brain communications · 2026Article
- Review
- Circadian attributes of neurological and psychiatric disorders as basis for their medication chronotherapy.Advanced drug delivery reviews · 2025Review
- Optimising anti-seizure medication timing using a dynamic network model of seizure rhythms.Frontiers in network physiology · 2025Article
- Developmental mechanisms underlying pediatric epilepsy.Frontiers in neurology · 2025Review
- Anti-seizure medication tapering correlates with daytime delta band power reduction in the cortex.Brain communications · 2025Article
- Chronobiology in Paediatric Neurological and Neuropsychiatric Disorders: Harmonizing Care with Biological Clocks.Journal of clinical medicine · 2024Review
- Chronic intracranial EEG recordings and interictal spike rate reveal multiscale temporal modulations in seizure states.Brain communications · 2023Article
- Biological rhythms and epilepsy treatment.Frontiers in neurology · 2023Review
- Sleep and epilepsy: A snapshot of knowledge and future research lines.Journal of sleep research · 2022Review
- Fluctuations in EEG band power at subject-specific timescales over minutes to days explain changes in seizure evolutions.Human brain mapping · 2022Article
- Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link.International journal of molecular sciences · 2021Review
- Chronopharmacology in Therapeutic Drug Monitoring-Dependencies between the Rhythmics of Pharmacokinetic Processes and Drug Concentration in Blood.Pharmaceutics · 2021Review
- Cycles in epilepsy.Nature reviews. Neurology · 2021Review
- Climate change and epilepsy: Insights from clinical and basic science studies.Epilepsy & behavior : E&B · 2021Review
- The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsy.Science advances · 2020Article
- Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy.Frontiers in neurology · 2020Article
- Circadian Rhythms and Epilepsy: A Suitable Case for Absence Epilepsy.Frontiers in neurology · 2020Review
- The Molecular Genetic Interaction Between Circadian Rhythms and Susceptibility to Seizures and Epilepsy.Frontiers in neurology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately one-third of patients with epilepsy continue to have seizures despite antiepileptic therapy. Many seizures occur in diurnal, sleep/wake, circadian, or even monthly patterns. The relationship between biomarkers and state changes is still being investigated, but early results suggest that some of these patterns may be related to endogenous circadian patterns whereas others may be related to wakefulness and sleep or both. Chronotherapy, the application of treatment at times of greatest seizure susceptibility, is a technique that may optimize seizure control in selected patients. It may be used in the form of differential dosing, as preparations designed to deliver sustained or pulsatile drug delivery or in the form of 'zeitgebers' that shift endogenous rhythms. Early trials in epilepsy suggest that chronopharmacology may provide improved seizure control compared with conventional treatment in some patients. The present article reviews chronopharmacology in the treatment of epilepsy as well as future treatment avenues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.