ArticleJournal of physiology and biochemistry2013
Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats.
Article in Journal of physiology and biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Gastroprotective effects of ethanolic leaf extracts of Matricaria chamomilla L. and Albizia lebbeck L. against indomethacin-induced gastric ulcer in Wistar rats: modulation of oxidative stress and inflammatory cytokines.Journal of molecular histology · 2026Article
- Comparative Efficacy of Coriander Seed Extract-Loaded Selenium Nanoparticles and DMSA in Restoring Antioxidant/Apoptotic Balance of Lead-Induced Hepatotoxicity.Cell biochemistry and biophysics · 2026Article
- Article
- Gastroprotective Effect of 2,3-Dimethylquinoxaline Against Indomethacin-Induced Gastric Ulcer in Rat.Journal of inflammation research · 2024Article
- Ferulic Acid Treats Gastric Ulcer via Suppressing Oxidative Stress and Inflammation.Life (Basel, Switzerland) · 2023Article
- Freshwater Clam Extract Attenuates Indomethacin-Induced Gastric Damage In Vitro and In Vivo.Foods (Basel, Switzerland) · 2022Article
- Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use.Molecules (Basel, Switzerland) · 2022Review
- Piceatannol Affects Gastric Ulcers Induced by Indomethacin: Association of Antioxidant, Anti-Inflammatory, and Angiogenesis Mechanisms in Rats.Life (Basel, Switzerland) · 2022Article
- Therapeutic efficiency of adipose-derived mesenchymal stem cells in healing of experimentally induced gastric ulcers in rats.Anatomy & cell biology · 2021Article
- Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity.International journal of molecular sciences · 2021Article
- Interplay of Biochemical, Genetic, and Immunohistochemical Factors in the Etio-Pathogenesis of Gastric Ulcer in Rats: A Comparative Study of the Effect of Pomegranate Loaded Nanoparticles Versus Pomegranate Peel Extract.Frontiers in physiology · 2021Article
- Induction of COX-1, suppression of COX-2 and pro-inflammatory cytokines gene expression by moringa leaves and its aqueous extract in aspirin-induced gastric ulcer rats.Molecular biology reports · 2019Article
- Chemical composition and protective role ofHeliyon · 2019Article
- Improvement of gastroprotective and anti-ulcer effect of kenaf seed oil-in-water nanoemulsions in rats.Food science and biotechnology · 2018Article
- Mast cells and pro-inflammatory cytokines roles in assessment of grape seeds extract anti-inflammatory activity in rat model of carrageenan-induced paw edema.Iranian journal of basic medical sciences · 2018Article
- ANTI-ULCEROGENIC EFFICACY AND MECHANISMS OF EDIBLE AND NATURAL INGREDIENTS IN NSAID-INDUCED ANIMAL MODELS.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Review
- Protective effect of grape seed and skin extract against high-fat diet-induced liver steatosis and zinc depletion in rat.Digestive diseases and sciences · 2014Article
- The protective effect of aged garlic extract on nonsteroidal anti-inflammatory drug-induced gastric inflammations in male albino rats.Evidence-based complementary and alternative medicine : eCAM · 2014Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indomethacin (IND) is a non-steroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions. In this study, we investigated the protective effect of selenium (SEL), grape seed extract (GSE), and both on IND-induced gastric mucosal ulcers in rats. Sprague-Dawley rats (200-250 g) were given SEL, GSE, and both by oral gavage for 28 days, and then gastric ulcers were induced by oral administration of 25 mg/kg IND. Malondialdehyde (MDA), non-enzymatic (reduced glutathione, GSH) and enzymatic (superoxide dismutase, catalase, and glutathione peroxidase) antioxidants, prostaglandin E2 (PGE2) in gastric mucosa, and serum tumor necrosis factor alpha (TNF-α) were measured. Moreover, gastric ulcer index and preventive index were determined. Indomethacin increased the gastric ulcer index, MDA, TNF-α, and decreased PGE2 and non-enzymatic (GSH) and enzymatic (superoxide dismutase, catalase, and glutathione peroxidase) antioxidants. Pretreatment with SEL, GSE, and both significantly decreased the gastric ulcer index, MDA, and TNF and increased antioxidants and PGE2. Histopathological observations confirm the gastric ulcer index and biochemical parameters. Selenium and GSE have a protective effect against IND-induced gastric ulcers through prevention of lipid peroxidation, increase of GSH, activation of radical scavenging enzymes, PGE2 generation, and anti-inflammatory activity. Co-administration of GSE and SEL is more effective than GSE or SEL alone.
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