SynthesisHuman genetics2013
Genome-wide association study in Han Chinese identifies three novel loci for human height.
Synthesis in Human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed.
- Functional analysis of NPR2 variants supports the therapeutic rationale for CNP in short stature.American journal of human genetics · 2026Article
- Your height affects your health: genetic determinants and health-related outcomes in Taiwan.BMC medicine · 2022Article
- Association of CYP19A1 and CYP1A2 genetic polymorphisms with type 2 diabetes mellitus risk in the Chinese Han population.Lipids in health and disease · 2020Article
- Article
- Association of polymorphism in the VEGFA gene 3'-UTR +936T/C with susceptibility to biliary atresia in a Southern Chinese Han population.Journal of clinical laboratory analysis · 2018Article
- Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan.Scientific reports · 2017Article
- Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994.eLife · 2016Article
- Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts.Scientific reports · 2016Article
- Regulation of body growth.Current opinion in pediatrics · 2015Review
- The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2015Article
- Susceptibility loci revealed for bovine respiratory disease complex in pre-weaned holstein calves.BMC genomics · 2014Article
- Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans.Human molecular genetics · 2014Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Human height is a complex genetic trait with high heritability but discovery efforts in Asian populations are limited. We carried out a meta-analysis of genome-wide association studies (GWAS) for height in 6,534 subjects with in silico replication of 1,881 subjects in Han Chinese. We identified three novel loci reaching the genome-wide significance threshold (P < 5 × 10(-8)), which mapped in or near ZNF638 (rs12612930, P = 2.02 × 10(-10)), MAML2 (rs11021504, P = 7.81 × 10(-9)), and C18orf12 (rs11082671, P = 1.87 × 10(-8)). We also confirmed two loci previously reported in European populations including CS (rs3816804, P = 2.63 × 10(-9)) and CYP19A1 (rs3751599, P = 4.80 × 10(-10)). In addition, we provided evidence supporting 35 SNPs identified by previous GWAS (P < 0.05). Our study provides new insights into the genetic determination of biological regulation of human height.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.