Trial reportPsychopharmacology2013
Neural substrates of acupuncture in the modulation of cravings induced by smoking-related visual cues: an fMRI study.
Trial report in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Differences in Magnitude of Cue Reactivity Across Durations of Smoking History: A Meta-analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Pooled it
- Global Trends and Performances of Magnetic Resonance Imaging Studies on Acupuncture: A Bibliometric Analysis.Frontiers in neuroscience · 2020Pooled it
- Shared and distinct brain activation patterns of acupoints HT7, ST36, and KI4: a task-based fMRI study.Frontiers in neurology · 2025Article
- Functional magnetic resonance imaging studies of acupuncture at ST36: a coordinate-based meta-analysis.Frontiers in neuroscience · 2023Review
- Acupuncture combined with auricular acupressure for smoking cessation and its effects on tobacco dependence and smoking behavior among Hong Kong smokers: a multicenter pilot clinical study.Chinese medicine · 2022Article
- Effects of acupuncture stimulation on brain activation induced by cue-elicited alcohol craving.Neural regeneration research · 2022Article
- Comparison between Acupuncture and Nicotine Replacement Therapies for Smoking Cessation Based on Randomized Controlled Trials: A Systematic Review and Bayesian Network Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Progress of Acupuncture Therapy in Diseases Based on Magnetic Resonance Image Studies: A Literature Review.Frontiers in human neuroscience · 2021Review
- The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction.Neural plasticity · 2020Article
- Cigarette Smoking in South Korea: A Narrative Review.Korean journal of family medicine · 2020Article
- Clinical application of single acupoint (HT7).Integrative medicine research · 2019Article
- Effects of acupuncture on craving after tobacco cessation: a resting-state fMRI study based on the fractional amplitude of low-frequency fluctuation.Quantitative imaging in medicine and surgery · 2019Article
- Effectiveness of auricular acupuncture combined with nicotine replacement therapy for smoking cessation.Tobacco induced diseases · 2018Article
- Acupuncture on the Stress-Related Drug Relapse to Seeking.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- The Effects of Acupuncture Stimulation for Brain Activation and Alcohol Abstinence Self-Efficacy: Functional MRI Study.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Acupuncture therapy for drug addiction.Chinese medicine · 2016Article
- The Status of the Quality Control in Acupuncture-Neuroimaging Studies.Evidence-based complementary and alternative medicine : eCAM · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleCue reactivity is a key factor in modulating motivational and goal-directed behaviors associated with compulsive drug intake and relapse. Smoking-associated cues produce smoking urges and cravings and are accompanied by the activation of brain regions involved in attention, motivation, and reward.
objectivesWe investigated whether acupuncture ameliorates cravings induced by smoking-related visual cues, and we explored the neural mechanisms underlying the effects of acupuncture on modulating smoking urges.
methodsAfter 36 h of smoking abstinence, 25 right-handed male smokers underwent fMRI, during which smoking-related and neutral visual cues were presented. Twelve subjects were treated with real acupuncture (RA) at HT7 and 13 subjects received sham acupuncture (SA). During the scanning sessions, craving scores to smoking-related visual cues were assessed before and after RA or SA treatment. The differences in brain responses to smoking vs. neutral cues after treatment between the RA and SA groups were detected using three-way ANOVAs (Cue × Session × Group).
resultsAfter treatment, the craving scores were significantly decreased in the RA group, as compared to the SA group. When we explored the neural substrates of acupuncture on the modulation of cravings induced by smoking cues, significant differences were found in the medial prefrontal cortex, the premotor cortex, the amygdala, the hippocampus, and the thalamus.
conclusionsThese findings suggest that acupuncture alleviates cue-induced cravings through the regulation of activity in brain regions involved in attention, motivation, and reward relative to craving scores in the initial abstinence phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.