ArticleStem cell research2013
Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background.
Article in Stem cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Recent Development of Advanced Fluorescent Molecular Probes for Organelle-Targeted Cell Imaging.Biosensors · 2023Review
- Article
- DNA damage in aging, the stem cell perspective.Human genetics · 2020Review
- mtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia.Molecular neurobiology · 2017Article
- Accumulation of DNA damage in the aged hematopoietic stem cell compartment.Seminars in hematology · 2017Review
- Article
- CTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells.PloS one · 2016Article
- Mitochondrial DNA mutations in single human blood cells.Mutation research · 2015Review
- Very low-level heteroplasmy mtDNA variations are inherited in humans.Journal of genetics and genomics = Yi chuan xue bao · 2013Article
- Mitochondria underlie different metabolism of hematopoietic stem and progenitor cells.Haematologica · 2013Article
- Apparent mtDNA sequence heterogeneity in single human blood CD34+ cells is markedly affected by storage and transport.Mutation researchArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
Marked sequence variation in the mtDNA control region has been observed in human single CD34(+) cells, which persist in vivo and are present also in differentiated hematopoietic cells. In this study, we analyzed 5071 single CD34(+) cells from 49 individuals (including 31 maternally related members from four families and 18 unrelated donors) in order to determine the mutation spectrum within the mtDNA control region in single cells, as related to aging and family genetic background. Many highly mutated sites among family members were hypervariable sites in the mtDNA control region. Further, CD34(+) cells from members of the same family also shared several unique mtDNA variants, suggesting pedigree-specific occurrence of these variants. Overall age-related accumulation of mtDNA mutations in CD34(+) cells varied in different families, suggesting a specific accumulation pattern, which might be modulated by family genetic background. Our current findings have implications for the occurrence of mtDNA mutations in hematopoietic stem cells and progenitors.
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