ArticleThe Journal of heredity
Estimating the population mutation rate from a de novo assembled Bactrian camel genome and cross-species comparison with dromedary ESTs.
Article in The Journal of heredity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Analysis of Genetic Diversity and Population Structure of Tarim and Junggar Bactrian Camels Based on Simplified GBS Genome Sequencing.Animals : an open access journal from MDPI · 2023Article
- Article
- Review of genetic diversity in Bactrian camel (Animal frontiers : the review magazine of animal agriculture · 2022Article
- Article
- Aspects of Molecular Genetics in Dromedary Camel.Frontiers in genetics · 2021Review
- Genomic signatures of domestication in Old World camels.Communications biology · 2020Article
- Old World camels in a modern world - a balancing act between conservation and genetic improvement.Animal genetics · 2019Review
- Comparative genomics suggests loss of keratin K24 in three evolutionary lineages of mammals.Scientific reports · 2019Article
- Genetic Improvement in Dromedary Camels: Challenges and Opportunities.Frontiers in genetics · 2019Article
- The history of Old World camelids in the light of molecular genetics.Tropical animal health and production · 2016Article
- The major histocompatibility complex in Old World camelids and low polymorphism of its class II genes.BMC genomics · 2016Article
- The de novo genome assembly and annotation of a female domestic dromedary of North African origin.Molecular ecology resources · 2016Article
- Assembly information services in the European Nucleotide Archive.Nucleic acids research · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Bactrian camel (Camelus bactrianus) and the dromedary (Camelus dromedarius) are among the last species that have been domesticated around 3000-6000 years ago. During domestication, strong artificial (anthropogenic) selection has shaped the livestock, creating a huge amount of phenotypes and breeds. Hence, domestic animals represent a unique resource to understand the genetic basis of phenotypic variation and adaptation. Similar to its late domestication history, the Bactrian camel is also among the last livestock animals to have its genome sequenced and deciphered. As no genomic data have been available until recently, we generated a de novo assembly by shotgun sequencing of a single male Bactrian camel. We obtained 1.6 Gb genomic sequences, which correspond to more than half of the Bactrian camel's genome. The aim of this study was to identify heterozygous single-nucleotide polymorphisms (SNPs) and to estimate population parameters and nucleotide diversity based on an individual camel. With an average 6.6-fold coverage, we detected over 116 000 heterozygous SNPs and recorded a genome-wide nucleotide diversity similar to that of other domesticated ungulates. More than 20 000 (85%) dromedary expressed sequence tags successfully aligned to our genomic draft. Our results provide a template for future association studies targeting economically relevant traits and to identify changes underlying the process of camel domestication and environmental adaptation.
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