ArticleThe Journal of clinical investigation2013
2-photon imaging of phagocyte-mediated T cell activation in the CNS.
Article in The Journal of clinical investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Article
- Review
- Border-Associated Macrophages: From Embryogenesis to Immune Regulation.CNS neuroscience & therapeutics · 2024Review
- Life history of a brain autoreactive T cell: From thymus through intestine to blood-brain barrier and brain lesion.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Endothelial cells and macrophages as allies in the healthy and diseased brain.Acta neuropathologica · 2024Review
- Imaging of brain barrier inflammation and brain fluid drainage in human neurological diseases.Cellular and molecular life sciences : CMLS · 2024Review
- Cellular and molecular imaging of CAR-T cell-based immunotherapy.Advanced drug delivery reviews · 2023Review
- Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Alpha4 beta7 integrin controls Th17 cell trafficking in the spinal cord leptomeninges during experimental autoimmune encephalomyelitis.Frontiers in immunology · 2023Article
- Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Review
- Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance.Journal of internal medicine · 2022Article
- Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging.Immunological reviews · 2022Review
- Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Imaging the dynamic interactions between immune cells and the neurovascular interface in the spinal cord.Experimental neurology · 2019Review
- Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment.Translational oncology · 2019Review
- LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System.Frontiers in immunology · 2019Article
- CNS-resident classical DCs play a critical role in CNS autoimmune disease.The Journal of clinical investigation · 2018Article
- Antigen-presenting cell diversity for T cell reactivation in central nervous system autoimmunity.Journal of molecular medicine (Berlin, Germany) · 2018Review
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoreactive T cells can infiltrate the CNS to cause disorders such as multiple sclerosis. In order to visualize T cell activation in the CNS, we introduced a truncated fluorescent derivative of nuclear factor of activated T cells (NFAT) as a real-time T cell activation indicator. In experimental autoimmune encephalomyelitis, a rat model of multiple sclerosis, we tracked T cells interacting with structures of the vascular blood-brain barrier (BBB). 2-photon imaging documented the cytoplasmic-nuclear translocation of fluorescent NFAT, indicative of calcium-dependent activation of the T cells in the perivascular space, but not within the vascular lumen. The activation was related to contacts with the local antigen-presenting phagocytes and was noted only in T cells with a high pathogenic potential. T cell activation implied the presentation of an autoantigen, as the weakly pathogenic T cells, which remained silent in the untreated hosts, were activated upon instillation of exogenous autoantigen. Activation did not cogently signal long-lasting arrest, as individual T cells were able to sequentially contact fresh APCs. We propose that the presentation of local autoantigen by BBB-associated APCs provides stimuli that guide autoimmune T cells to the CNS destination, enabling them to attack the target tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.